Obtaining of Hydrogels using PVA and HEC for Adipose Tissue Regeneration

Abstract

Polyvinyl Alcohol (PVA) and Hydroxy Ethyl Cellulose (HEC) were used to prepare hydrogel for tissue regeneration. Female rabbits were used to evaluate the obtained hydrogels for the regeneration of adipose tissue. Mechanical and biocompatible properties were evaluated. AFM (Atomic Force Microcopy) and SEM (Scanning Electron Microscopy) showed the roughness around 5.447 nm and pore size from 1 to 7.9 μm. In vivo tests were conducted during two years in female rabbits. Histological images showed stable fat formation over long-term without adverse reaction or necrosis. The obtained results indicated that PHEC30 hydrogel may provide a viable approach for the regeneration of adipose tissue in female rabbits as first step as an alternative solution for women who suffered a radical mastectomy.