Quantification of the Content of Ten (10) Brands of Metronidazole Infusion Marketed in Abuja Metropolis by UV Spectroscopic Method

Abstract

The proliferation of substandard drugs is a major public health challenge, especially in developing countries which lacks adequate resources to effectively monitor their prevalence. Currently, there are no reliable statistics on the level of incidence of fake drugs in Nigeria. The quality of medicines is an integral part in ensuring that pharmaceutical products are fit for their intended use, comply with requirements of marketing authorization and do not expose consumers to risks. For this to be achieved, there must be a system of quality assurance, which incorporates aspects including product development, manufacturing, distribution, and storage. This study aimed at quantifying the content of ten (10) brands of metronidazole infusion marketed in Abuja by UV-Spectroscopic method. Ten (10) brands of metronidazole were purchased in different pharmacies within the city of Abuja and were assayed using UV-Spectroscopic method as stated in British Pharmacopoeia 2017 edition. All the ten (10) brands of metronidazole that were assayed had a percentage content of 100.97% to 108.15%. From the study carried out, all the brands of metronidazole infusion complied with the content uniformity test as stated in the British Pharmacopeia.