Efficacy of Different Doses of Dexmedetomidine in Blood Pressure to Laryngoscopy in Controlled Hypertensive Patient: A Randomized Control Trial

Rumana Afroz, Rabeya Begum, S. S. Alam, Nurul Islam, Mahin Muntakim, Zunaid, Jabed
{"title":"Efficacy of Different Doses of Dexmedetomidine in Blood Pressure to Laryngoscopy in Controlled Hypertensive Patient: A Randomized Control Trial","authors":"Rumana Afroz, Rabeya Begum, S. S. Alam, Nurul Islam, Mahin Muntakim, Zunaid, Jabed","doi":"10.3329/BMJ.V48I3.51790","DOIUrl":null,"url":null,"abstract":"Control of blood pressure during anesthesia is very crucial. Laryngoscopic manipulation and endotracheal intubation are always a matter of concern which capable of producing tachycardia, arrhythmias and hypertension which is generally well tolerated in healthy patient. In hypertensive patient cardiovascular response to laryngoscopy and intubation is exaggerated.  This study was conducted to assess the efficacy of different doses of dexmedetomidine in reduction of blood pressure during laryngoscopy and intubation in controlled hypertensive patient. This prospective Randomized controlled trial was carried out among 60 patients belonging to American Society of Anesthesiologists (ASA) Physical Status II posted for elective general anesthesia. Patients were randomly divided into three groups where each groups contain twenty with fixed card sampling. Group A consisted of twenty (20) patients who were received IV dexmedetomidine 0.5 µg/kg diluted to 50 ml with normal saline.  Group B consisted of twenty (20) patients who were received IV dexmedetomidine 0.75 µg/kg diluted to 50 ml with normal saline. Group C consisted of twenty (20) patients who were received IV dexmedetomidine 1 µg/kg diluted to 50 ml with normal saline. Each infusions were started 10 minutes prior induction of general anesthesia and were given over 10 minutes. Baseline systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial blood pressure (MAP) were measured by one volunteer anesthesiologists by non-invasive blood pressure monitor. Following laryngoscopy and endotracheal intubation, the parameters recorded were SBP, DBP and MAP at 1, 3 and 5 min after intubation by non-invasive blood pressure monitor. The primary outcome measures were blood pressure responses after intubation and secondary outcome measures were to note down any adverse effects associated with drugs.  In this study baseline readings of SBP, DBP and MAP were almost similar in all three groups and statistically not significant. Maximum intubation response was seen at 1 min post intubation in all the three groups. The mean SBP of group A varied from 144.8±8.4 mmHg to 118.5±4.4 mmHg that of group B varied from 134.8±4.1 to 122.0±4.2 mmHg and then group C varied from 126.5±15.5 mmHg to 103.8±8.4 mmHg during different evaluation period (p 0.05). Dexmedetomidine in doses of 0.75 µg/kg was more effective compared to 0.05 µg/kg and 1µg/kg in attenuating blood pressure response to laryngoscopy and endotracheal intubation without producing adverse effects in control hypertensive patients. \nBangladesh Med J. 2019 Sep; 48 (3): 1-8","PeriodicalId":8711,"journal":{"name":"Bangladesh Medical Journal","volume":"268 1","pages":"1-8"},"PeriodicalIF":0.0000,"publicationDate":"2021-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bangladesh Medical Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3329/BMJ.V48I3.51790","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Control of blood pressure during anesthesia is very crucial. Laryngoscopic manipulation and endotracheal intubation are always a matter of concern which capable of producing tachycardia, arrhythmias and hypertension which is generally well tolerated in healthy patient. In hypertensive patient cardiovascular response to laryngoscopy and intubation is exaggerated.  This study was conducted to assess the efficacy of different doses of dexmedetomidine in reduction of blood pressure during laryngoscopy and intubation in controlled hypertensive patient. This prospective Randomized controlled trial was carried out among 60 patients belonging to American Society of Anesthesiologists (ASA) Physical Status II posted for elective general anesthesia. Patients were randomly divided into three groups where each groups contain twenty with fixed card sampling. Group A consisted of twenty (20) patients who were received IV dexmedetomidine 0.5 µg/kg diluted to 50 ml with normal saline.  Group B consisted of twenty (20) patients who were received IV dexmedetomidine 0.75 µg/kg diluted to 50 ml with normal saline. Group C consisted of twenty (20) patients who were received IV dexmedetomidine 1 µg/kg diluted to 50 ml with normal saline. Each infusions were started 10 minutes prior induction of general anesthesia and were given over 10 minutes. Baseline systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial blood pressure (MAP) were measured by one volunteer anesthesiologists by non-invasive blood pressure monitor. Following laryngoscopy and endotracheal intubation, the parameters recorded were SBP, DBP and MAP at 1, 3 and 5 min after intubation by non-invasive blood pressure monitor. The primary outcome measures were blood pressure responses after intubation and secondary outcome measures were to note down any adverse effects associated with drugs.  In this study baseline readings of SBP, DBP and MAP were almost similar in all three groups and statistically not significant. Maximum intubation response was seen at 1 min post intubation in all the three groups. The mean SBP of group A varied from 144.8±8.4 mmHg to 118.5±4.4 mmHg that of group B varied from 134.8±4.1 to 122.0±4.2 mmHg and then group C varied from 126.5±15.5 mmHg to 103.8±8.4 mmHg during different evaluation period (p 0.05). Dexmedetomidine in doses of 0.75 µg/kg was more effective compared to 0.05 µg/kg and 1µg/kg in attenuating blood pressure response to laryngoscopy and endotracheal intubation without producing adverse effects in control hypertensive patients. Bangladesh Med J. 2019 Sep; 48 (3): 1-8
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
不同剂量右美托咪定对控制高血压患者喉镜检查血压的疗效:一项随机对照试验
在麻醉过程中控制血压是至关重要的。喉镜操作和气管插管一直是人们关注的问题,可能产生心动过速、心律失常和高血压,而健康患者通常耐受良好。高血压患者对喉镜和插管的心血管反应被夸大。本研究旨在评估不同剂量右美托咪定在控制高血压患者喉镜检查和插管时降低血压的效果。这项前瞻性随机对照试验是在60名患者中进行的,这些患者属于美国麻醉医师协会(ASA)物理状态II,他们接受选择性全身麻醉。患者随机分为三组,每组20人,固定卡片抽样。A组20例患者静脉滴注右美托咪定0.5µg/kg,用生理盐水稀释至50 ml。B组20例患者静脉注射右美托咪定0.75µg/kg,用生理盐水稀释至50 ml。C组20例患者静脉滴注右美托咪定1µg/kg,用生理盐水稀释至50 ml。每次输注在全麻诱导前10分钟开始,输注时间超过10分钟。基线收缩压(SBP)、舒张压(DBP)和平均动脉压(MAP)由一名志愿麻醉医师用无创血压监测仪测量。经喉镜检查和气管插管后,插管后1、3、5 min用无创血压监测仪记录收缩压、舒张压和MAP。主要结果测量是插管后的血压反应,次要结果测量是记录与药物相关的任何不良反应。在这项研究中,三组的收缩压、舒张压和MAP基线读数几乎相似,且无统计学意义。三组均在插管后1分钟出现最大插管反应。A组在144.8±8.4 mmHg ~ 118.5±4.4 mmHg之间变化,B组在134.8±4.1 ~ 122.0±4.2 mmHg之间变化,C组在126.5±15.5 mmHg ~ 103.8±8.4 mmHg之间变化(p < 0.05)。与0.05µg/kg和1µg/kg剂量的右美托咪定相比,0.75µg/kg剂量的右美托咪定在降低喉镜检查和气管插管患者血压反应方面更有效,且不会产生不良反应。孟加拉国医学杂志2019年9月;48 (3): 1-8
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Drug Abuse of Professional Drivers: Experience from Referral Dope Test Pattern of Eosinophil and Neutrophil/ Lymphocyte Ratio in Different Stages of Chronic Kidney Disease. Clinicobiochemical Parameters of Cytomegalovirus IgM and IgG positive Biliary Atresia and their Relation with Serological Titer in Infants. Diagnosis and Prognosis of Neonatal Septic Arthritis from it’s Early Clinical Characteristics: Experience from a Tertiary Care Hospital Thyroid Collision Tumour: Concurrence of Two Thyroid Malignancy
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1