{"title":"A Brief Communication REDUCED ABSORPTION OF PARACETAMOL FOLLOWING CIMETIDINE IN HEALTHY VOLUNTEERS","authors":"M. Garba, A. Mustapha, M. Bakare, I. Aguye","doi":"10.1080/107691897229586","DOIUrl":null,"url":null,"abstract":"Cimetidine has not been shown to affect the pharmacokinetics of paracetamol. However, when the protocol was modified in such a way that paracetamol was taken 1 h after cimetidine, there was a significant effect on its absorption. The C and K (absorption constant) were significantly reduced ( p < .001 for the max difference between the two cases-control and treated). Lag time was greatly increased ( p <.001). This indicates that the therapeutic efficacy of paracetamol may be affected.","PeriodicalId":87425,"journal":{"name":"Toxic substance mechanisms","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1997-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Toxic substance mechanisms","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/107691897229586","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
Abstract
Cimetidine has not been shown to affect the pharmacokinetics of paracetamol. However, when the protocol was modified in such a way that paracetamol was taken 1 h after cimetidine, there was a significant effect on its absorption. The C and K (absorption constant) were significantly reduced ( p < .001 for the max difference between the two cases-control and treated). Lag time was greatly increased ( p <.001). This indicates that the therapeutic efficacy of paracetamol may be affected.
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