Calcium leak induced arrhythmias in mouse sino-atrial node and ventricle cells: A simulation study.

Qingjie Wang, S. Kharche, Gareth M. Jones, Cunjin Luo, Chengchun Tang, Henggui Zhang
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Abstract

Bradycardia is found to be a complication during catecholaminergic polymorphic ventricular tachycardia in which calcium leak plays a pivotal role. In this computational study, we determined the effects of sarcoplasmic reticulum calcium leak on the function of sino-atrial node and ventricular model cells.
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钙漏致小鼠心房结和心室细胞心律失常的模拟研究。
心动过缓是儿茶酚胺能多形性室性心动过速的并发症,其中钙漏起关键作用。在本计算研究中,我们测定了肌浆网钙渗漏对窦房结和心室模型细胞功能的影响。
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