An efficient synthesis of antitumor 4-anilinofuro[2,3-b]quinoline derivatives

Abstract

We have described the partial synthesis of antitumor 4-anilinofuro [2, 3-b] quinoline derivatives from dictamnine, a natural alkaloid. Due to the limited supply of natural starting material, we report herein an efficient total synthesis of the title compounds from the known 3, 4-dichlorofuro [2, 3-b] quinoline in two steps.