Comparison of Tandem Quadrupole Mass Spectrometry and Orbitrap High Resolution Mass Spectrometry for Analysis of Pharmaceutical Residues in Biota Samples

I. Reinholds, I. Pugajeva, V. Bartkevičs
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引用次数: 3

Abstract

Abstract This research demonstrates the development of reliable multi-component methods for the detection of antibiotic residues in environmental biota. The efficiency of analytical performance of ultra high performance liquid chromatography (UHPLC) techniques with triple quadrupole (QqQ-MS/MS) and Orbitrap high-resolution mass spectrometry (Orbitrap-HRMS) detectors is discussed. Antibiotic residues in biota samples collected in Latvia were analysed. The contamination status was determined as rather low within acceptable levels set by the European Union Regulations.
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串联四极杆质谱与轨道阱高分辨率质谱分析生物样品中药物残留的比较
摘要本研究为环境生物群中抗生素残留的可靠多组分检测方法的发展提供了基础。讨论了三重四极杆(QqQ-MS/MS)和Orbitrap高分辨率质谱(Orbitrap- hrms)检测器的超高效液相色谱(UHPLC)分析效率。分析了在拉脱维亚收集的生物群样本中的抗生素残留。污染状况被确定为相当低,在欧洲联盟条例规定的可接受水平之内。
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