Interactions of Metal ions withTrimethoprim and Metformin

Abstract

In this work, metal complexes of trimethoprim mixed metformin were synthesized and characterized by solubility studies, percentage metal analysis, UV-Vis spectroscopy, IR spectroscopy and magnetic susceptibility and conductivity measurements. The IR spectra showedthat the trimethoprim coordinated as a monodentate ligand coordinating to the metal ions via the pyrimidine N(1), metformin acts as a bidentate ligand coordinating through the iminonitrogens. The infrared spectra bands at 450 cm -1 and 530 cm -1 is ascribed to M –N and M –O bond respectively indicating the formation of these complexes. The magnetic moment data showed that all the complexes were paramagnetic with values ranging from 1.39 to 6.0 B.M, except [Zn(TMP)(MET)(H2O)Cl2] which was diamagnetic. The conductivity results revealed that all the synthesised complexes were non-electrolytes, while the antibacterial studies of the mixed ligand complexes displayed moderate antimicrobial activity in comparison with the free ligands.