N. M. Mockler, S. Engilberge, M. Rennie, C. Raston, P. B. Crowley
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引用次数: 2
Abstract
ABSTRACT Water soluble calixarenes are versatile mediators of protein assembly, including the fabrication of crystalline frameworks. Here, we report the X-ray crystal structure of cytochrome c (cytc) co-crystallised with two different calixarenes: phosphonato-calix[6]arene (pclx6 ) and sulfonato-calix[8]arene (sclx8 ). Each calixarene type acts as an independent molecular glue that mediates cytc dimers within the crystal. The calixarene-mediated dimers combine to yield chains of cytc-sclx8 -cytc-pclx6-pclx6 repeating units. These supramolecular copolymer units pack together, via a protein-protein interface, to yield a porous dendrite-like assembly. Interestingly, the tri-component framework has features in common with previously reported structures of cytc in complex with pclx6 or sclx8 . Known protein-calixarene ‘building blocks’ combine in novel ways to yield the tri-component assembly, highlighting the versatility of calixarene molecular glues in protein crystal engineering. Graphical abstract
期刊介绍：
Supramolecular Chemistry welcomes manuscripts from the fields and sub-disciplines related to supramolecular chemistry and non-covalent interactions. From host-guest chemistry, self-assembly and systems chemistry, through materials chemistry and biochemical systems, we interpret supramolecular chemistry in the broadest possible sense. Interdisciplinary manuscripts are particularly encouraged. Manuscript types include: high priority communications; full papers; reviews, and; Methods papers, techniques tutorials highlighting procedures and technologies that are important to the field. We aim to publish papers in a timely fashion and as soon as a paper has been accepted and typeset it will be published in electronic form on the Latest articles section of the website. The two most important review criteria are that the paper presents high-quality work that fits generally into the broad spectrum of activities in the supramolecular chemistry field. Under normal circumstances, Supramolecular Chemistry does not consider manuscripts that would be more suitable in a highly specialized journal. This includes, but is not limited to, those based mostly or exclusively on topics such as solid state/X-ray structures, computational chemistry, or electrochemistry. .
The two most important review criteria are that the paper presents high-quality work that fits generally into the broad spectrum of activities in the supramolecular chemistry field.
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