Evaluation of Neutrophil-to-Lymphocyte Ratio Among Ischemic Stroke Subtypes and Stroke Severity

Dhrumil Shah, Rajeswari Rajan, A. Batra, I. Anand, A. Saraf, P. Sethi
{"title":"Evaluation of Neutrophil-to-Lymphocyte Ratio Among Ischemic Stroke Subtypes and Stroke Severity","authors":"Dhrumil Shah, Rajeswari Rajan, A. Batra, I. Anand, A. Saraf, P. Sethi","doi":"10.1177/25166085221095183","DOIUrl":null,"url":null,"abstract":"Introduction: Recently, neutrophil-to-lymphocyte ratio (NLR) has been proven to be useful in predicting severity, mortality, and morbidity of stroke. NLR is low cost and yet not used widely as a biomarker to predict prognosis. Aims: We evaluated the association of NLR in severity of stroke and ischemic stroke subtypes. Methodology: A total of 69 subjects with ischemic stroke onset within 24 h were included in the study and categorized according to TOAST classification. National Institutes of Health Stroke Scale was used to determine stroke severity at admission. Samples were obtained within 24 h of stroke onset and NLR measured which was later correlated with severity and subtypes of stroke. Results: NLR and severity of stroke showed statistically significant association (P < .05). Median (interquartile range [IQR]) of NLR was significantly high in severe cases (7.1 [4.03-7.698]), as compared to others. The area under the receiver operating characteristic curve for NLR to predict the stroke severity was 6.07 [area under the curve 0.764; 95% confidence interval: 0.647 to 0.858). When NLR was more than 6.07, there was 90.90% chances of moderate-to-severe stroke and with milder stroke, 93.10% had NLR of less than equal to 6.07. NLR and stroke subtypes also showed statistically significant association (P < .05). Median (IQR) of NLR in embolic stroke was significantly high (4.75 [2.95-8.2]), as compared to other stroke subtypes. Conclusion: NLR, at a cut-off 6, has moderate sensitivity and higher specificity in predicting stroke severity and NLR was high in embolic stroke among other stroke subtypes.","PeriodicalId":93323,"journal":{"name":"Journal of stroke medicine","volume":"3 1","pages":"40 - 47"},"PeriodicalIF":0.0000,"publicationDate":"2022-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of stroke medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/25166085221095183","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1

Abstract

Introduction: Recently, neutrophil-to-lymphocyte ratio (NLR) has been proven to be useful in predicting severity, mortality, and morbidity of stroke. NLR is low cost and yet not used widely as a biomarker to predict prognosis. Aims: We evaluated the association of NLR in severity of stroke and ischemic stroke subtypes. Methodology: A total of 69 subjects with ischemic stroke onset within 24 h were included in the study and categorized according to TOAST classification. National Institutes of Health Stroke Scale was used to determine stroke severity at admission. Samples were obtained within 24 h of stroke onset and NLR measured which was later correlated with severity and subtypes of stroke. Results: NLR and severity of stroke showed statistically significant association (P < .05). Median (interquartile range [IQR]) of NLR was significantly high in severe cases (7.1 [4.03-7.698]), as compared to others. The area under the receiver operating characteristic curve for NLR to predict the stroke severity was 6.07 [area under the curve 0.764; 95% confidence interval: 0.647 to 0.858). When NLR was more than 6.07, there was 90.90% chances of moderate-to-severe stroke and with milder stroke, 93.10% had NLR of less than equal to 6.07. NLR and stroke subtypes also showed statistically significant association (P < .05). Median (IQR) of NLR in embolic stroke was significantly high (4.75 [2.95-8.2]), as compared to other stroke subtypes. Conclusion: NLR, at a cut-off 6, has moderate sensitivity and higher specificity in predicting stroke severity and NLR was high in embolic stroke among other stroke subtypes.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
中性粒细胞/淋巴细胞比值在缺血性卒中亚型和卒中严重程度中的评价
近年来,中性粒细胞与淋巴细胞比值(NLR)已被证明可用于预测中风的严重程度、死亡率和发病率。NLR成本低,但尚未广泛用作预测预后的生物标志物。目的:我们评估NLR与脑卒中严重程度和缺血性脑卒中亚型的关系。方法:将69例24 h内发病的缺血性卒中患者纳入研究,按TOAST分类。入院时采用美国国立卫生研究院卒中量表确定卒中严重程度。在脑卒中发生24小时内采集样本,并测量NLR, NLR随后与脑卒中的严重程度和亚型相关。结果:NLR与脑卒中严重程度有统计学意义(P < 0.05)。重症NLR的中位数(四分位数间距[IQR])明显高于其他病例(7.1[4.03-7.698])。NLR预测脑卒中严重程度的受试者工作特征曲线下面积为6.07,曲线下面积为0.764;95%置信区间:0.647 ~ 0.858)。当NLR大于6.07时,发生中重度卒中的几率为90.90%;当NLR小于6.07时,发生轻度卒中的几率为93.10%。NLR与脑卒中亚型也有统计学意义(P < 0.05)。栓塞性卒中NLR的中位数(IQR)明显高于其他卒中亚型(4.75[2.95-8.2])。结论:NLR在预测脑卒中严重程度方面具有中等敏感性和较高特异性,在其他脑卒中亚型中,NLR在栓塞性脑卒中中较高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
A Study of the Correlation of Pulsatility Index by Transcranial Doppler in the Clinical Outcome of Patients with Cerebral Venous Sinus 
Thrombosis Acute Ischaemic Stroke in a Young Adult in Sub-Saharan Africa: A Case Report of Post-strangulation Carotid Artery Dissection The Effect of Biological Sex on a County Pre-hospital Stroke Initiative COVID and Vaccine-related Cerebral Venous Thrombosis Expert Consensus on Improving Stroke Care Ecosystem in India
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1