Inhibition of scrapie prion propagation

Jörg Tatzelt, Konstanze F. Winklhofer
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Abstract

Prion diseases are characterized by the propagation of an abnormally folded protein, denoted scrapie prion protein (PrPSc). Here we review results from our group which reveale different possibilities to interfere with the propagation and accumulation of PrPSc in scrapie-infected cell lines and animal models.

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痒病朊病毒繁殖的抑制作用
朊病毒疾病的特征是一种异常折叠蛋白的繁殖,称为痒病朊病毒蛋白(PrPSc)。在这里,我们回顾了我们小组的结果,这些结果揭示了干扰痒病感染细胞系和动物模型中PrPSc繁殖和积累的不同可能性。
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Guest Editorial: From man to mice – from mice to man Editorial: Gene Funct. Dis. 1-2/2002 Quantitation of inflammatory und proliferative genes as disease markers in laser-microdissected, formalin-fixed and paraffinized glomeruli from human renal biopsies Structural variation in a novel zinc finger protein and investigation of its role in Hirschsprung disease Cell adhesion and matrix remodeling genes identified by co-expression analysis
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