Effect of Milk on Dissolution of Theophylline Sustained-Release Preparations.

Abstract

THEODUR® Tablets 100 (TDR·T) and THEODUR® Dry Symp 20%(TDR·DS) are sustained-releasepme pamations of theophylline. The dissolution test was used to examine the effects of TDR·T and TDR·DS soaked with milk on the release of theophylline from these preparations. The dissolution of theophylline from TDR·T soaked with milk was slower than that of the control thus indicating a delay in the release of theophylline. Milk did not affect the dissolution of theophylline from TDR·DS. In conclusion, the diffemence between the structures of TDR·T and TDR·DS seemed to produce dif5erences in the dissolution of theophylline soaked with milk. Accordingly, patients are recommended to take TDR·T with water apd not with milk.