Biomarkers for Early Diagnosis of Acute Kidney Injury

Abstract

Acute kidney injury (AKI) is a common and potentially life-threatening conditionassociated with morbidity and mortality. Currently, the standard diagnostic tools for the detection of AKI are monitoring of urinary output and serum creatinine (sCr), both of which are markers of kidney function but not kidney injury. Novel AKI biomarkers have made significant contributions to our understanding of the molecular under pinnings of AKI, they could also have use as molecular phenotyping tools that facilitate the identification of patients who could benefit from a specific intervention, even a biomarker-targeted intervention and they were proved to be useful in facilitating early diagnosis, guiding targeted interventions and monitoring the disease progression and resolution.