Assessment and Association between Lipid and Hormonal Profile in Nonpregnant Females Having Polycystic Ovarian Syndrome

Abstract

Introduction: PCOS is a gynecological endocrine disorder with ovarian dysfunction, hyperandrogenism, infertility, hirsutism, acne, dyslipidemia, and menstrual irregularities. Objectives: The aim of our study is to evaluate the fluctuations of hormonal profile regarding PCOS in fasting and random state as well as the possible risk factor of cardiovascular disorders towards PCOS. Method: Blood was taken by CSLI (Clinical and Laboratory Standards Institution) procedure. Merk and Roach diagnostic systems were used to analyze lipid and hormonal profiles. Results: Significant differences were observed in cholesterol (p=0.004), HDL, LDL (p<0.001) in fasting PCOS vs. control, LDL, HDL (p<0.001), cholesterol (p=0.08), lipid profile ratios in fasting vs. random PCOS, FSH (p=0.01), Progesterone (p=0.000), Estradiol (p=0.000), LH/FSH (p=0.04) in fasting PCOS vs. control, LH (p=0.04) in fasting vs. random PCOS. Significant positive correlation was found among estradiol with cholesterol (r=0.376, p=0.08), LDL (r=0.39, p=0.006) in fasting PCOS, estradiol with cholesterol (r=-0.334, p=0.02), FSH with LDL (r=0.36, p=0.01), progesterone with HDL (r=0.338, p=0.02) in random PCOS. Conclusion: This study assesses the worth of lipid profile in PCOS towards cardiovascular risk factors because lipid and hormonal profile have a direct correlation with PCOS. Besides CVDs hormonal profile fluctuates frequently in random and fasting state. To diagnose treat PCOS properly, patients should be monitored in the fasting state.