Phytochemical and Antibacterial Evaluations of Chloroform Extract of Mondia whitei (Hook F) skeels

Tanzania Journal of Science Pub Date : 2022-12-30 DOI:10.4314/tjs.v48i4.2

A. Shehu, Ojochide Inikpi Egwemi, O. Ajayi, Abdul Hamid

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Abstract

Mondia whitei, also known as Mondia, is an aromatic plant of Apocynaceae family. It is used as aphrodisiac, antidepressant, fertility medication and to improve appetite. The present study aimed to evaluate the phytochemical and antibacterial properties of the plant. The chloroform extract of M. whitei was screened for its antibacterial effects using agar diffusion method against five bacterial strains (Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae and Salmonella typhi). The extract was active against S. typhi, K. pneumoniae and S. aureus at 400, 400 and 200 mg/mL, respectively. The antibacterial activity of the extract was observed in a dose-dependent manner and was compared with standard antibiotic, ciprofloxacin. The phytochemical screening of the extract revealed the presence of flavonoids, terpenoids, cardiac glycosides, steroids, phlobatannins and phytosterols. The GC-MS analysis of the extract afforded seventeen (17) compounds with major components being n-hexadecanoic acid (23.80%). The exhibited antibacterial activities justify the ethnomedicinal uses of M. whitei root. Keywords: Mondia whitei, GC-MS, Antibacterial activity, Phytochemical

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白念珠菌(Hook F)骨氯仿提取物的植物化学和抗菌评价

白月牙，又称月牙，是夹竹桃科的芳香植物。它被用作壮阳药，抗抑郁药，生育药物和改善食欲。本研究旨在评价该植物的植物化学和抗菌特性。采用琼脂扩散法筛选白支原体氯仿提取物对金黄色葡萄球菌、铜绿假单胞菌、大肠埃希菌、肺炎克雷伯菌和伤寒沙门菌5株细菌的抑菌效果。提取物在400、400和200 mg/mL浓度下对伤寒沙门氏菌、肺炎克雷伯菌和金黄色葡萄球菌均有抑制作用。以剂量依赖性方式观察提取物的抑菌活性，并与标准抗生素环丙沙星进行比较。植物化学筛选结果显示，提取液中含有黄酮类、萜类、心糖苷类、甾体类、玻璃钢蛋白类和植物甾醇类化合物。GC-MS分析得到17个化合物，主要成分为正十六酸(23.80%)。所表现出的抗菌活性证明了白根的民族药用价值。关键词:白念珠菌，GC-MS，抗菌活性，植物化学

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Tanzania Journal of Science

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