The Role of Astrocytes in the Central Nervous System: Physiological and Pathophysiological Conditions

Abstract

shown that these diseases are associated with severe inflammation and as trocytes are among the mos t important cells that cause inflammation. Reactive as trocytes play a role in the pathology of various neurological diseases, such as Alzheimer’s disease, Parkinson’s disease, lateral amyotrophic sclerosis, multiple sclerosis, and Huntington’s. Alterations in neurotransmitters, cellular connections, receptors, signaling pathways (especially in the field of inflammation), secretion of inflammatory factors, aqueous channels, secretion of growth factors, protein deposition, ionic homeos tasis, and finally, changes in the size and number of as trocytes have been considered as the mos t important pathogenic mechanisms in as trocytes. Conclusion: Regulation of reactive as trocytes could be an effective clinical s trategy for the treatment of neurological and psychological diseases.s