CHAPTER 2. Importance of C–H Hydrogen Bonding in Asymmetric Catalysis

Abstract

This chapter describes the important roles of nonclassical C–H hydrogen bonds in asymmetric catalysis. Recently, many asymmetric catalytic reactions have demonstrated that weak C–H hydrogen bond interactions play important roles in selectivity. This chapter introduces the historical background of C–H hydrogen bonds, describes computational analyses of C–H hydrogen bonds in asymmetric catalysis and presents notable examples of asymmetric catalytic reactions in which C–H hydrogen bonds play important roles in selectivity.