{"title":"Aldehydes and Acetals","authors":"M. Morandi, S. Maberti","doi":"10.1002/0471435139.TOX073","DOIUrl":null,"url":null,"abstract":"More than 300 aldehydes occur in foods, water, and air. Due to the electrophilicity of the carbonyl carbon, particularly when proximal to a carbon–carbon double bond, aldehydes react with thiols and amines to form protein–protein, DNA–protein, and DNA–DNA cross-links. Despite their potential for causing cell damage, toxicological and exposure data for a large number of aldehydes are lacking. Inhalation and ingestion studies have demonstrated that a number of aldehydes are irritants and can induce tumors in animal models. Formaldehyde which is a suspected carcinogen is the most widely studied of these compounds. The physicochemical properties of saturated aldehydes are summarized. Toxicological and health effects are presented. \n \n \nKeywords: \n \nSaturated aliphatic aldehydes; \nFormaldehyde; \nUrea-formaldehyde resins; \nEPA; \nClean Air Act; \nFlavoring agents; \nUnsaturated aliphatic aldehydes; \nHalogenated aldehydes; \nAliphatic dialdehydes; \nAromatic aldehydes; \nHeterocyclic aldehydes; \nAcetals","PeriodicalId":19820,"journal":{"name":"Patty's Toxicology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2001-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Patty's Toxicology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/0471435139.TOX073","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
More than 300 aldehydes occur in foods, water, and air. Due to the electrophilicity of the carbonyl carbon, particularly when proximal to a carbon–carbon double bond, aldehydes react with thiols and amines to form protein–protein, DNA–protein, and DNA–DNA cross-links. Despite their potential for causing cell damage, toxicological and exposure data for a large number of aldehydes are lacking. Inhalation and ingestion studies have demonstrated that a number of aldehydes are irritants and can induce tumors in animal models. Formaldehyde which is a suspected carcinogen is the most widely studied of these compounds. The physicochemical properties of saturated aldehydes are summarized. Toxicological and health effects are presented.
Keywords:
Saturated aliphatic aldehydes;
Formaldehyde;
Urea-formaldehyde resins;
EPA;
Clean Air Act;
Flavoring agents;
Unsaturated aliphatic aldehydes;
Halogenated aldehydes;
Aliphatic dialdehydes;
Aromatic aldehydes;
Heterocyclic aldehydes;
Acetals
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