Frequency of Hyperprolactinemia in PCOS and its Association with Female Infertility

Abstract

Introduction: Infertility is a critical health concern partially due to intricacy in its causes and striving for its prevention, diagnosis and treatment. Various researches have documented a close linkage between polycystic ovary syndrome and hyperprolactinemia. Aims & Objectives: This study was aimed to determine the frequency of hyperprolactinemia in PCOS and its association with infertility in PCOS subjects. Place and duration of study: It was a cross sectional study, conducted during April 2017 and September 2017 at Aziz Fatimah Hospital, Faisalabad, Pakistan. Material & Methods: It was a cross sectional study which was conducted at Aziz Fatimah Hospital, Faisalabad, Pakistan from April to September 2017. This study comprised of 88 female subjects of 17-35 years old who included PCOS subjects and age matched controls. Hyperprolactinemia was assessed by the measurement of serum prolactin levels which were measured by chemiluminescence immunoassay technique (CLIA). SPSS version 22 was used for the statistical analysis of the data. Results: Out of total 88 female participants, 61.4% of polycystic ovary syndrome subjects had hyperprolactinemia as compared to this 36.4% of controls had hyperprolactinemia. Pearson correlation also revealed significant positive association of hyperprolactinemia with infertility. Conclusion: Hyperprolactinemia was frequently seen in polycystic ovary syndrome females as well as raised BMI was also found. Raised prolactin levels are strongly associated with female infertility. Key words: Hyperprolactinemia, Infertilty, Polycystic Ovary Syndrome.