Roles of noncoding RNAs in chronic obstructive pulmonary disease.

Abstract

Chronic obstructive pulmonary disease (COPD) is a chronic heterogeneous disease characterized by persistent airflow obstruction and variable clinical presentations.[1,2] A lack of understanding regarding the molecular mechanisms underlying COPD makes the identification of critical molecules involved in COPD crucial for the development of novel diagnostic measures and therapeutic strategies. In recent decades, wide-ranging profiling methods such as microarrays and next-generation sequencing have made it easier to identify RNA transcripts that do not encode proteins, referred to as noncoding RNAs (ncRNAs).[3] NcRNAs comprise a diverse range of RNA species, characterized according to their length, shape, and location. Many ncRNAs are involved in epigenetic and posttranscriptional gene regulation, including microRNAs (miRNAs), tRNA-derived small RNAs (tsRNAs) and PIWI-interacting RNAs (piRNAs).[4] Long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) can fold into complex secondary structures that facilitate their interactions with DNA, RNA, and protein.[4] Additionally, lncRNAs and circRNAs can bind to miRNAs in a competitive endogenous RNA (ceRNA) network that prevents targeted mRNA degradation.[5,6] Recent studies have shown that ncRNAs play crucial roles in multiple pathophysiological processes associated with COPD.[5,7,8] A better understanding of the role of ncRNAs in COPD could contribute to the detection of biomarkers and the identification of new therapeutic targets. Here, we summarize the current findings regarding the potential role of ncRNAs, especially miRNAs, lncRNAs, and circRNAs. Additionally, we propose considerations regarding present and future research in this area.