Analysis of COVID-19 clinical course among vaccinated against SARS-CoV-2 people in the Khabarovsk krai

Abstract

Aim. To analyze clinical manifestations of novel coronavirus infection among vaccinated population of the Khabarovsk krai with breakthrough infection.Materials and methods. Analysis was based on official data including information on COVID-19 breakthrough infections provided by Khabarovsk krai Rospotrebnadzor regional office. Statistical analysis included calculation of Spearman's rank correlation, odds ratio.Results. A relatively small proportion (0.7%) of breakthrough COVID-cases that occurred among Khabarovsk residents vaccinated against SARS-CoV-2 was shown during analyzed period of time. The highest risk of contracting COVID-19 was revealed among people aged over 50 years. Course of breakthrough COVID-19 infection was mostly mild ‒ 61.0% (95% CI: 54.2‒67.6%). In most cases COVID-19 manifested itself as acute respiratory viral infection ‒ 66.7% (95% CI: 60.0‒73.0%). A significant negative correlation was noted between levels of blood saturation and duration of the disease (ρ=-0.82; p<0.05). Duration of COVID- 19 among vaccinated people was 16 days in for patients treated in an outpatient facility and 17 days for hospitalized patients in average. Most common clinical manifestations of COVID-19, noted by more than half of the respondents, were hyperthermia ‒ 55.7% (95% CI: 48.8–62.5%), weakness and cough ‒ 65.7% each (95% CI: 59.1–72,2%).Conclusion. Obtained data testify in favor of significant protective potential of vaccines against COVID-19.