{"title":"Simple and Direct Quantitative Analysis for Quinidine Drug in Fish Tissues","authors":"Yuan-Chin Chen, H. Abdelhamid, Hui-Fen Wu","doi":"10.5478/MSL.2017.8.1.8","DOIUrl":null,"url":null,"abstract":"Analysis of quinidine for fish tissues using single drop microextraction (SDME) coupled with atmospheric pressure matrix assisted laser desorption/ionization mass spectrometry (AP-MALDI-MS) are reported. Optimization conditions; such as extraction solvent, extraction time, pH of the aqueous solution, salt additions (NaCl), stirring rate, matrix type and concentration are investigated. Linear dynamic range (μM), limit of detection, relative recovery%, and enrichment factor are 0.08-9.2, 0.05, 94.8±3.198.5±3.3%, 4.34±0.28-4.40±0.30, respectively. SDME-AP-MALDI-MS shows good intraday and interday reproducibility.","PeriodicalId":18238,"journal":{"name":"Mass Spectrometry Letters","volume":"317 1","pages":"8-13"},"PeriodicalIF":0.4000,"publicationDate":"2017-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"7","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mass Spectrometry Letters","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5478/MSL.2017.8.1.8","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"SPECTROSCOPY","Score":null,"Total":0}
引用次数: 7
Abstract
Analysis of quinidine for fish tissues using single drop microextraction (SDME) coupled with atmospheric pressure matrix assisted laser desorption/ionization mass spectrometry (AP-MALDI-MS) are reported. Optimization conditions; such as extraction solvent, extraction time, pH of the aqueous solution, salt additions (NaCl), stirring rate, matrix type and concentration are investigated. Linear dynamic range (μM), limit of detection, relative recovery%, and enrichment factor are 0.08-9.2, 0.05, 94.8±3.198.5±3.3%, 4.34±0.28-4.40±0.30, respectively. SDME-AP-MALDI-MS shows good intraday and interday reproducibility.
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