Herbal Phytomedicine 'Irisolidone' in chronic diseases: Biological Efficacy and pharmacological activity.

Abstract

BACKGROUND Plant derived products have been used in the medicine as a source of bioactive molecules due to its therapeutic potential. Nowadays plants derived products have been used for the development of novel drug leads. Polyphenols are an important class of secondary metabolites found to be present in plant material and their derived products. Polyphenols are having an important role in the nutrition for human beings. It also has a significant role in plant resistance against pests and diseases. Scientific studies have proven the biological importance of flavonoids in medicine and other allied health sectors. Anti-oxidant, analgesic, anti-microbial, anti-inflammatory, anti-viral, anti-tumor and anti-allergic activities are the important pharmacological features of flavonoids. Irisolidone is an important isoflavone found to be present in Pueraria lobata flowers. METHODS In order to know the medicinal importance and therapeutic benefit of irisolidone, numerous scientific research data have been collected from Google, Google Scholar, PubMed, Science Direct and Scopus. Pharmacological activities scientific data of irisolidone has been collected and analyzed in the present works to know the health beneficial aspects of irisolidone. Detailed pharmacological activities of irisolidone have been investigated through scientific data analysis of scientific research works. RESULTS Scientific research data analysis of irisolidone revealed the anti-inflammatory, anti-angiogenic, anti-cancer, anti-platelet, anti-oxidant, anti-hyperlipidemic, immunomodulating, hepatoprotective and estrogenic activities. However biological effect of irisolidone on gastric system, aldose reductase enzymes, malignant gliomas and JC virus has been also investigated. Scientific data analysis revealed the significance of analytical tools for separation and identification of irisolidone. CONCLUSION Present work signified the biological importance and therapeutic potential of irisolidone in the medicine.