CO2 laser therapy for management of stress urinary incontinence in women: a systematic review and meta-analysis.

IF 2.6 4区 医学 Q2 UROLOGY & NEPHROLOGY Therapeutic Advances in Urology Pub Date : 2023-11-10 eCollection Date: 2023-01-01 DOI:10.1177/17562872231210216
Bandr Hafidh, Saeed Baradwan, Hassan M Latifah, Abdulrahim Gari, Hussein Sabban, Hanin Hassan Abduljabbar, Afaf Tawfiq, Ghaidaa Farouk Hakeem, Alya Alkaff, Nabigah Alzawawi, Radiah Iskandarani, Kausar Khurshid, Kausar Aisha Syed, Ammar Y Alkhiary, Ibtihal Abdulaziz Bukhari, Maha Al Baalharith, Ahmed Abu-Zaid
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Abstract

Background: Carbon dioxide (CO2) laser therapy is an emerging treatment for women with stress urinary incontinence (SUI).

Objectives: To examine the efficacy of CO2 laser therapy for management of SUI-related symptoms in women.

Design: A systematic review and meta-analysis of randomized controlled trials and cohort studies.

Data sources and methods: Four databases were screened until January 2023. All efficacy continuous endpoints were assessed via subtraction of the posttreatment from pretreatment values. The data were summarized as mean difference (MD) with 95% confidence interval (CI) using the random-effects model.

Results: A total of 15 studies with 700 patients were analyzed. CO2 laser therapy significantly decreased the 1-h pad weights at 3 months [n = 5 studies, MD = -3.656 g, 95% CI (-5.198, -2.113), p < 0.001], 6 months [n = 6 studies, MD = -6.583 g, 95% CI (-11.158, -2.008), p = 0.005], and 12 months [n = 6 studies, MD = -3.726 g, 95% CI (-6.347, -1.106), p = 0.005]. Moreover, CO2 laser therapy significantly decreased the International Consultation of Incontinence Questionnaire-Urinary Incontinence Short Form Scores at 3 months [n = 10 studies, MD = -4.805, 95% CI (-5.985, -3.626), p < 0.001] and 12-months [n = 6 studies, MD = -3.726, 95% CI (-6.347, -1.106), p = 0.005]. Additionally, CO2 laser therapy significantly decreased the Pelvic Floor Impact Questionnaire scores at 6 months [n = 2 studies, MD = -11.268, 95% CI (-18.671, -3.865), p = 0.002] and 12 months [n = 2 studies, MD = -10.624, 95% CI (-18.145, -3.103), p = 0.006]. Besides, CO2 laser therapy significantly decreased the Urogenital Distress Inventory-6 scores at 3 months [n = 2 studies, MD = -21.997, 95% CI (-32.294, -11.699), p < 0.001], but not at 6 months [n = 3 studies, MD = -3.034, 95% CI (-7.357, 1.259), p = 0.169]. Lastly, CO2 laser therapy significantly increased the Vaginal Health Index Score at 6 months [n = 2 studies, MD = 2.826, 95% CI (0.013, 5.638), p = 0.047] and 12 months [MD = 1.553, 95% CI (0.173, 2.934), p = 0.027].

Conclusion: CO2 laser therapy improved the SUI-related symptoms in women. To obtain solid conclusions, future studies should be well-designed with standardized settings, consistent therapeutic protocols, and long-term follow-up periods.

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CO2激光治疗女性压力性尿失禁:系统回顾和荟萃分析。
背景:二氧化碳激光治疗是一种治疗女性压力性尿失禁(SUI)的新方法。目的:探讨CO2激光治疗女性sui相关症状的疗效。设计:对随机对照试验和队列研究进行系统回顾和荟萃分析。数据来源和方法:筛选4个数据库至2023年1月。所有疗效连续终点均通过前处理值减去后处理值来评估。采用随机效应模型将数据汇总为95%置信区间(CI)的均值差(MD)。结果:共分析了15项研究,700例患者。CO2激光治疗显著降低3个月时1小时的pad重量[n = 5项研究,MD = -3.656 g, 95% CI (-5.198, -2.113), p n = 6项研究,MD = -6.583 g, 95% CI (-11.158, -2.008), p = 0.005]和12个月[n = 6项研究,MD = -3.726 g, 95% CI (-6.347, -1.106), p = 0.005]。此外,CO2激光治疗显著降低3个月时尿失禁国际咨询问卷-尿失禁短表评分[n = 10项研究,MD = -4.805, 95% CI (-5.985, -3.626), p n = 6项研究,MD = -3.726, 95% CI (-6.347, -1.106), p = 0.005]。此外,CO2激光治疗显著降低骨盆底影响问卷评分在6个月[n = 2项研究,MD = -11.268, 95% CI (-18.671, -3.865), p = 0.002]和12个月[n = 2项研究,MD = -10.624, 95% CI (-18.145, -3.103), p = 0.006]。此外,CO2激光治疗显著降低3个月时泌尿生殖窘迫量表-6评分[n = 2项研究,MD = -21.997, 95% CI (-32.294, -11.699), p n = 3项研究,MD = -3.034, 95% CI (-7.357, 1.259), p = 0.169]。最后,CO2激光治疗显著提高阴道健康指数评分在6个月[n = 2项研究,MD = 2.826, 95% CI (0.013, 5.638), p = 0.047]和12个月[MD = 1.553, 95% CI (0.173, 2.934), p = 0.027]。结论:CO2激光治疗可改善女性sui相关症状。为了获得可靠的结论,未来的研究应该精心设计标准化的环境、一致的治疗方案和长期的随访期。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.70
自引率
0.00%
发文量
39
审稿时长
10 weeks
期刊介绍: Therapeutic Advances in Urology delivers the highest quality peer-reviewed articles, reviews, and scholarly comment on pioneering efforts and innovative studies across all areas of urology. The journal has a strong clinical and pharmacological focus and is aimed at clinicians and researchers in urology, providing a forum in print and online for publishing the highest quality articles in this area. The editors welcome articles of current interest across all areas of urology, including treatment of urological disorders, with a focus on emerging pharmacological therapies.
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