Influence of glycosylation on the development and treatment of neuroblastoma.

Robert Campbell
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Abstract

Neuroblastoma is a solid malignancy observed in pediatric patients that develops when neuroblasts are unable to mature, leading to unregulated proliferation and tumor formation. Neuroblastoma commonly manifests in the adrenal gland, but may also form in the neck, chest, or spinal cord. Neuroblastoma is heterogeneous and aggressive in nature, leading to high treatment failure, morbidity, and mortality rates. Lewis family glycans, as part of the Core 2 O- glycans, play a key role in neuroblastoma malignant cell behavior in MYCN-amplified cell lines. Current treatment approaches for neuroblastoma include chemotherapy, surgery, and radiation. These approaches are faced with physiological and cellular barriers, including the influence of glycosylation in cancer diseases. Studies have confirmed that the inhibition of mucin glycosylation has improved effectiveness of cytotoxic drug agents employed against solid malignancies such as with pancreatic cancer, yet little research is available regarding the influence of glycosylated proteins for other diseases. This article reviews the effect of glycosylation on the development and treatment of neuroblastoma.
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糖基化对神经母细胞瘤发展及治疗的影响。
神经母细胞瘤是在儿科患者中观察到的一种实体恶性肿瘤,当神经母细胞无法成熟时发展,导致不受调节的增殖和肿瘤形成。神经母细胞瘤通常表现在肾上腺,但也可能在颈部、胸部或脊髓形成。神经母细胞瘤具有异质性和侵袭性,导致高治疗失败率、发病率和死亡率。Lewis家族聚糖作为Core 2 O-聚糖的一部分,在mycn扩增细胞系中神经母细胞瘤恶性细胞行为中起关键作用。目前神经母细胞瘤的治疗方法包括化疗、手术和放疗。这些方法面临着生理和细胞障碍,包括糖基化在癌症疾病中的影响。研究证实,抑制粘蛋白糖基化可提高用于治疗实体恶性肿瘤(如胰腺癌)的细胞毒性药物的有效性,但关于糖基化蛋白对其他疾病的影响的研究很少。本文就糖基化在神经母细胞瘤的发展和治疗中的作用作一综述。
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