Huiyu Li, F. Lei, Yugang Wang, Xin-yue Xiao, Jun Hu, Xianlong Cheng, Dongming Xing, Lei Hua, Ruichao Lin, L. Du
{"title":"Effect of Euphorbia kansui on urination and kidney AQP2, IL-1β and TNF-α mRNA expression of mice injected with normal saline","authors":"Huiyu Li, F. Lei, Yugang Wang, Xin-yue Xiao, Jun Hu, Xianlong Cheng, Dongming Xing, Lei Hua, Ruichao Lin, L. Du","doi":"10.4268/CJCMM20120514","DOIUrl":null,"url":null,"abstract":"OBJECTIVE To observe the effect of Euphorbia kansui (E. KS) alcohol extracts on urination and kidney-related expressions of mice injected with normal saline and to discuss its impact on kidney. METHOD Mice intraperitoneally injected with normal saline were observed for urination and changes in kidney-related histiocytic factors of after intragastrical administration of E. KS and compared with normal mice. RESULT E. KS alcohol extracts can promote urination of mice injected with normal saline and enhance peripheral serum creatinine, with no obvious pathological change showed in tissue sections. It had a certain effect on reducing AQP2 expression and enhancing TNF-alpha expression. CONCLUSION Euphorbia kansui in large dose has a remarkable effect on kidney but may be accompanied with pathological reactions to some extent, especially the dose of 1.2 g x kg(-1). The pathological reactions may be related with increased serum creatinine and TNF-alpha expression.","PeriodicalId":9835,"journal":{"name":"China Journal of Chinese Matera Medica","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2012-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"China Journal of Chinese Matera Medica","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4268/CJCMM20120514","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
Abstract
OBJECTIVE To observe the effect of Euphorbia kansui (E. KS) alcohol extracts on urination and kidney-related expressions of mice injected with normal saline and to discuss its impact on kidney. METHOD Mice intraperitoneally injected with normal saline were observed for urination and changes in kidney-related histiocytic factors of after intragastrical administration of E. KS and compared with normal mice. RESULT E. KS alcohol extracts can promote urination of mice injected with normal saline and enhance peripheral serum creatinine, with no obvious pathological change showed in tissue sections. It had a certain effect on reducing AQP2 expression and enhancing TNF-alpha expression. CONCLUSION Euphorbia kansui in large dose has a remarkable effect on kidney but may be accompanied with pathological reactions to some extent, especially the dose of 1.2 g x kg(-1). The pathological reactions may be related with increased serum creatinine and TNF-alpha expression.
目的观察宽遂醇提物对生理盐水注射小鼠排尿及肾脏相关表达的影响，探讨其对肾脏的影响。方法小鼠腹腔注射生理盐水后，观察大鼠排尿情况及大鼠肾相关组织细胞因子的变化，并与正常小鼠比较。结果E. KS醇提物能促进生理盐水注射小鼠排尿，提高外周血肌酐水平，组织切片无明显病理改变。具有一定的降低AQP2表达、增强tnf - α表达的作用。结论大剂量大戟对肾脏有显著的影响，但可能伴有一定程度的病理反应，尤其是1.2 g x kg(-1)剂量。病理反应可能与血清肌酐和tnf - α表达升高有关。
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