A Delta-Sigma Approach for Ion Channel Based Biosensor Arrays

M. Bennati, F. Lodesani, M. Crescentini, A. Mariani, M. Tartagni
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引用次数: 3

Abstract

Detection of target substances at very low concentration by using molecular stochastic sensing might open new directions for diagnostic tools. This paper presents a compact and low-cost electronic system to record events derived from ligand-gated ion channels embedded in an array of artificial lipid bilayer substrates. In our approach, a Surface Mount Technology electronic system has been designed to be interfaced with a 4x3 array of spots. The currents through each spot of one row are concurrently readout and digitized by three current-mode DeltaSigma (Delta Sigma) analog to digital converters. The output data streams are sent to a digital acquisition card for being recorded and post-processed by a PC.
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离子通道生物传感器阵列的Delta-Sigma方法
利用分子随机传感技术检测极低浓度的目标物质可能为诊断工具开辟新的方向。本文介绍了一种紧凑和低成本的电子系统,用于记录嵌入在一系列人工脂质双分子层底物中的配体门控离子通道产生的事件。在我们的方法中,一个表面贴装技术电子系统被设计成与4x3阵列的点接口。通过一行的每个点的电流同时读出,并通过三个电流模式的德尔塔西格玛(德尔塔西格玛)模拟数字转换器数字化。输出数据流被送到数字采集卡,由PC机进行记录和后处理。
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