Comparative study between the efficacy of botulinum toxin type A versus carboxytherapy in the treatment of postacne scars

S. Fikry, Wafaa Mahmoud, Hoda Elsebaey
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Abstract

Background Acne scarring remains a challenge to treat. Both botulinum toxin type A (BTX-A) and carboxytherapy (CXT) are considered novel treatment modalities for acne scars. Aim This study aimed to compare the efficacy and safety of BTX-A versus CXT in the treatment of postacne scars. Patients and methods Forty patients aged 18–50 years, with mild to severe postacne scars, were enrolled in this study and were divided randomly and equally into two groups: group A included 20 patients who underwent three sessions of an intralesional injection into postacne scars by BTX-A at a 3-week interval and group B included 20 patients who underwent three sessions of CXT on postacne scars at a 3-week interval. Evaluation of the clinical response to treatment was performed every 3 weeks and 1 month after the last session by photos and the global scarring grading system and patient satisfaction was assessed. Results There was a significant improvement in the degree of scar severity before and after treatment in both groups. There was no significant difference between improvements in both groups, indicating that both modalities of treatment yielded similar net results. Conclusion Both BTX-A and CXT can be effective and safe therapeutic options for the treatment of postacne scars with no significant side effects.
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A型肉毒杆菌毒素与羧酸疗法治疗痤疮后疤痕疗效的比较研究
痤疮疤痕的治疗仍然是一个挑战。A型肉毒杆菌毒素(BTX-A)和羧酸疗法(CXT)都被认为是治疗痤疮疤痕的新方法。目的比较BTX-A与CXT治疗痤疮后瘢痕的疗效和安全性。患者与方法40例年龄在18-50岁,有轻度至重度痤疮后瘢痕的患者,随机平均分为两组:A组20例,每隔3周接受3次BTX-A病灶内注射痤疮后瘢痕,B组20例,每隔3周接受3次痤疮后瘢痕CXT治疗。在最后一次治疗后每3周和1个月通过照片和全球疤痕分级系统评估临床疗效,并评估患者满意度。结果两组患者治疗前后瘢痕严重程度均有明显改善。两组之间的改善没有显著差异,表明两种治疗方式产生了相似的净结果。结论BTX-A和CXT治疗痤疮后瘢痕均安全有效,无明显副作用。
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