Structure and Antibiotic Resistance of the Main Causative agents of Infections Associated with the Provision of Medical care

N. Voropaeva, U. Nemchenko, E. Grigorova, N. L. Bel'kova, N. Chemezova, E. Savilov
{"title":"Structure and Antibiotic Resistance of the Main Causative agents of Infections Associated with the Provision of Medical care","authors":"N. Voropaeva, U. Nemchenko, E. Grigorova, N. L. Bel'kova, N. Chemezova, E. Savilov","doi":"10.31631/2073-3046-2023-22-1-68-73","DOIUrl":null,"url":null,"abstract":"Relevance. The problem of healthcare-associated infections (HCAI) is becoming increasingly important in epidemiological, social and economic terms. The most serious threat to hospital patients is multidrug-resistant Gram-negative organisms such as Pseudomonas aeruginosa and Klebsiella pneumoniae. The purpose of the study was to determine the etiological structure and sensitivity to antimicrobial agents of infectious agents associated with the provision of medical care in a children's multidisciplinary hospital. Materials and methods. The strains used in the work were obtained from patients aged from one to 15 years with severe infectious diseases. Additionally, swabs were taken from environmental objects. Bacteriological identification of selected strains was performed using standardized bacteriological algorithms and MALDI-TOF direct protein profiling of non-spore-forming microorganisms. Results. P. aeruginosa and K. pneumoniae were identified as the main causative agents of HAI with multiple resistance to AMPs in the children's multidisciplinary hospital, the source of which was mainly the respiratory tract. Multiple resistance to AMP was higher in K. pneumoniae, 38.9% of the studied isolates showed resistance to four drugs simultaneously. P. aeruginosa in 23.1% of cases was resistant to one AMP, in 15.4% - to two, four and seven AMPs. Conclusion. For a reasonable choice and optimization of antibacterial treatment of hospital patients, it is necessary to take into account the fact of wide circulation of hospital strains. Systematic monitoring of the constantly changing microbiological landscape of hospitals based on microbiological monitoring data and determining the levels of resistance to antimicrobial chemotherapy drugs will help reduce the risk and prevent the development of infections associated with healthcare.","PeriodicalId":11736,"journal":{"name":"Epidemiology and Vaccinal Prevention","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Epidemiology and Vaccinal Prevention","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31631/2073-3046-2023-22-1-68-73","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1

Abstract

Relevance. The problem of healthcare-associated infections (HCAI) is becoming increasingly important in epidemiological, social and economic terms. The most serious threat to hospital patients is multidrug-resistant Gram-negative organisms such as Pseudomonas aeruginosa and Klebsiella pneumoniae. The purpose of the study was to determine the etiological structure and sensitivity to antimicrobial agents of infectious agents associated with the provision of medical care in a children's multidisciplinary hospital. Materials and methods. The strains used in the work were obtained from patients aged from one to 15 years with severe infectious diseases. Additionally, swabs were taken from environmental objects. Bacteriological identification of selected strains was performed using standardized bacteriological algorithms and MALDI-TOF direct protein profiling of non-spore-forming microorganisms. Results. P. aeruginosa and K. pneumoniae were identified as the main causative agents of HAI with multiple resistance to AMPs in the children's multidisciplinary hospital, the source of which was mainly the respiratory tract. Multiple resistance to AMP was higher in K. pneumoniae, 38.9% of the studied isolates showed resistance to four drugs simultaneously. P. aeruginosa in 23.1% of cases was resistant to one AMP, in 15.4% - to two, four and seven AMPs. Conclusion. For a reasonable choice and optimization of antibacterial treatment of hospital patients, it is necessary to take into account the fact of wide circulation of hospital strains. Systematic monitoring of the constantly changing microbiological landscape of hospitals based on microbiological monitoring data and determining the levels of resistance to antimicrobial chemotherapy drugs will help reduce the risk and prevent the development of infections associated with healthcare.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
与提供医疗保健有关的感染的主要病原体的结构和抗生素耐药性
的相关性。卫生保健相关感染(HCAI)的问题在流行病学、社会和经济方面变得越来越重要。对医院病人最严重的威胁是多重耐药革兰氏阴性菌,如铜绿假单胞菌和肺炎克雷伯菌。本研究的目的是确定与儿童多学科医院提供医疗服务相关的感染性病原体的病原学结构和对抗菌药物的敏感性。材料和方法。工作中使用的菌株来自1至15岁患有严重传染病的患者。此外,从环境物体中提取棉签。选择菌株的细菌学鉴定采用标准化细菌学算法和MALDI-TOF非孢子形成微生物的直接蛋白质谱分析。结果。在儿童多学科医院,铜绿假单胞菌和肺炎克雷伯菌是HAI的主要病原体,并对抗菌药物多重耐药,其来源主要是呼吸道。肺炎克雷伯菌对AMP的多重耐药较高,38.9%的分离株同时对4种药物耐药。23.1%的铜绿假单胞菌对一种AMP有耐药性,15.4%的病例对两种、四种和七种AMP有耐药性。结论。为合理选择和优化医院患者抗菌药物治疗方案,必须考虑到医院菌株广泛传播的事实。根据微生物监测数据对医院不断变化的微生物状况进行系统监测,并确定对抗微生物化疗药物的耐药性水平,将有助于降低风险并预防与医疗保健相关的感染的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Serogroup B Protein Meningococcal Vaccines and the Formation of Immune Protection against Gonorrhea Obtaining and Characterization of Experimental Diagnostic Brucellosis Rabbit Sera for the Development of a National Standard for Brucellosis Serum New Russian Trivalent Hepatitis B Vaccine (Bubo®­-Unigep): Reactogenicity, Safety and Immunological Efficacy Bacterial Infections Transmitted by Ticks in Barnaul: Epidemiological and Epizootological Situation, Diagnostic Problems Factors Determining Adherence to Hand Antisepsis by Healthcare Workers during Pandemic Infection Spread (as exemplified by COVID­-19)
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1