{"title":"Articles of Significant Interest Selected from This Issue by the Editors","authors":"","doi":"10.1128/CVI.00573-16","DOIUrl":null,"url":null,"abstract":"Functional and Antigen-Specific Serum Antibodies Correlate with Protection against Shigella Infection in Humans Immunological correlates of protection against shigellosis remain ill defined. Shimanovich et al. (e00412-16) establish quantitative assays to measure Shigella-specific serum bactericidal antibody (SBA) and opsonophagocytic killing antibody (OPKA) and demonstrate that SBA and OPKA titers, as well as IpaBand VirG-specific IgG (IgG1) titers, are significantly correlated with reduced disease in EcSf2a-2-vaccinated and unvaccinated volunteers challenged with virulent Shigella flexneri 2a. Live-attenuated vaccine candidates CVD 1204 and CVD 1208S also elicit SBA and OPKA responses in clinical studies. This is the first demonstration of SBA, OPKA, and IpaBand VirG-specific IgG titers being associated with protection against shigellosis in humans. These findings are relevant for evaluation of protective immunity and vaccine efficacy.","PeriodicalId":10271,"journal":{"name":"Clinical and Vaccine Immunology","volume":"30 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2017-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical and Vaccine Immunology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1128/CVI.00573-16","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 0
Abstract
Functional and Antigen-Specific Serum Antibodies Correlate with Protection against Shigella Infection in Humans Immunological correlates of protection against shigellosis remain ill defined. Shimanovich et al. (e00412-16) establish quantitative assays to measure Shigella-specific serum bactericidal antibody (SBA) and opsonophagocytic killing antibody (OPKA) and demonstrate that SBA and OPKA titers, as well as IpaBand VirG-specific IgG (IgG1) titers, are significantly correlated with reduced disease in EcSf2a-2-vaccinated and unvaccinated volunteers challenged with virulent Shigella flexneri 2a. Live-attenuated vaccine candidates CVD 1204 and CVD 1208S also elicit SBA and OPKA responses in clinical studies. This is the first demonstration of SBA, OPKA, and IpaBand VirG-specific IgG titers being associated with protection against shigellosis in humans. These findings are relevant for evaluation of protective immunity and vaccine efficacy.
期刊介绍：
Cessation. First launched as Clinical and Diagnostic Laboratory Immunology (CDLI) in 1994, CVI published articles that enhanced the understanding of the immune response in health and disease and after vaccination by showcasing discoveries in clinical, laboratory, and vaccine immunology. CVI was committed to advancing all aspects of vaccine research and immunization, including discovery of new vaccine antigens and vaccine design, development and evaluation of vaccines in animal models and in humans, characterization of immune responses and mechanisms of vaccine action, controlled challenge studies to assess vaccine efficacy, study of vaccine vectors, adjuvants, and immunomodulators, immune correlates of protection, and clinical trials.
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