Primary cutaneous CD8+ T-cell lymphoma

Z. Aydi , B. Ben Dhaou , E. Ben Brahim , L. Baili , F. Boussema , S. Ketari , O. Cherif , A. Debbiche , L. Rokbani
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引用次数: 2

Abstract

Primary cutaneous aggressive CD8+ T-cell lymphoma is an extremely rare entity with distinct clinicopathological features. We report a case of a 28-year-old man that clinically presented with an ulcerated nodule on his trunk and extremities. Histopathologic sections showed an ulcerated epidermis with a diffuse lymphocytic infiltrate in the superficial dermis with focal epidermotropism. Immunohistochemically, the tumor cells were positive for CD3 and CD8 but negative for CD4, CD20, CD30 and CD56. Granzyme B was positif. He received UVB therapy subsequently associated to interferon with an important regression of the nodules.

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原发性皮肤CD8+ t细胞淋巴瘤
原发性皮肤侵袭性CD8+ t细胞淋巴瘤是一种非常罕见的疾病,具有独特的临床病理特征。我们报告一例28岁的男子,临床表现为溃疡结节在他的躯干和四肢。组织病理切片显示表皮溃疡,真皮浅层弥漫性淋巴细胞浸润,伴局灶性嗜表皮。免疫组化结果显示,肿瘤细胞CD3、CD8阳性,CD4、CD20、CD30、CD56阴性。颗粒酶B阳性。他接受了中波紫外线治疗,随后使用干扰素治疗,结节明显消退。
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