Z. Aydi , B. Ben Dhaou , E. Ben Brahim , L. Baili , F. Boussema , S. Ketari , O. Cherif , A. Debbiche , L. Rokbani
{"title":"Primary cutaneous CD8+ T-cell lymphoma","authors":"Z. Aydi , B. Ben Dhaou , E. Ben Brahim , L. Baili , F. Boussema , S. Ketari , O. Cherif , A. Debbiche , L. Rokbani","doi":"10.1016/j.jssdds.2011.08.002","DOIUrl":null,"url":null,"abstract":"<div><p>Primary cutaneous aggressive CD8<sup>+</sup> T-cell lymphoma is an extremely rare entity with distinct clinicopathological features. We report a case of a 28-year-old man that clinically presented with an ulcerated nodule on his trunk and extremities. Histopathologic sections showed an ulcerated epidermis with a diffuse lymphocytic infiltrate in the superficial dermis with focal epidermotropism. Immunohistochemically, the tumor cells were positive for CD3 and CD8 but negative for CD4, CD20, CD30 and CD56. Granzyme B was positif. He received UVB therapy subsequently associated to interferon with an important regression of the nodules.</p></div>","PeriodicalId":100847,"journal":{"name":"Journal of the Saudi Society of Dermatology & Dermatologic Surgery","volume":"16 1","pages":"Pages 25-28"},"PeriodicalIF":0.0000,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jssdds.2011.08.002","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Saudi Society of Dermatology & Dermatologic Surgery","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2210836X11000534","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
Abstract
Primary cutaneous aggressive CD8+ T-cell lymphoma is an extremely rare entity with distinct clinicopathological features. We report a case of a 28-year-old man that clinically presented with an ulcerated nodule on his trunk and extremities. Histopathologic sections showed an ulcerated epidermis with a diffuse lymphocytic infiltrate in the superficial dermis with focal epidermotropism. Immunohistochemically, the tumor cells were positive for CD3 and CD8 but negative for CD4, CD20, CD30 and CD56. Granzyme B was positif. He received UVB therapy subsequently associated to interferon with an important regression of the nodules.