Stripping voltammetric detection of nephrotoxic drug cefitizoxime in wastewater

Analytical Chemistry Research Pub Date : 2015-06-01 DOI:10.1016/j.ancr.2015.03.002

Jahangir Ahmad Rather , Rajeev Jain

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引用次数: 5

Abstract

The objective of the present work is to develop the stripping voltammetric method for determination of nephrotoxic drug cefitizoxime in pharmaceutical formulation and its application to wastewater analysis. Solubilized system of different surfactants viz. cationic, anionic and non-ionic influences the electrochemical response of cefitizoxime. Solubilized system of CTAB containing cefitizoxime enhanced the peak current while anionic and non-ionic showed an opposite effect. The current signal due to the reduction process is a function of concentration of the cefitizoxime, pH of medium, type of surfactant and accumulation time at electrode surface. The proposed SWCAdSV (Squarewave Cathodic Adsorptive Voltammtery) and DPCAdSV (Differential Pulse Cathodic Adsorptive Voltammetry) are linear over concentration range 1.732–6.901 μg/mL and 4.792–30.672 μg/mL with detection limit of 0.76 ng/mL and 2.63 ng/mL, respectively. The method is successfully applied for determination of cefitizoxime in pharmaceutical formulation and wastewater with mean percentage recovery of 99.73% and 98.51%, respectively.

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溶出伏安法检测废水中肾毒性药物头孢替肟

建立溶出伏安法测定制剂中肾毒性药物头孢替昔肟及其在废水分析中的应用。不同表面活性剂(阳离子、阴离子和非离子)的增溶体系对头孢替肟的电化学反应有影响。含头孢替昔肟的CTAB增溶体系增强了峰值电流，而阴离子和非离子体系则相反。还原过程产生的电流信号是头孢噻肟浓度、介质pH、表面活性剂类型和电极表面积累时间的函数。所建立的方波阴极吸附伏安法和差分脉冲阴极吸附伏安法在1.732 ~ 6.901 μg/mL和4.792 ~ 30.672 μg/mL范围内呈线性关系，检出限分别为0.76 ng/mL和2.63 ng/mL。该方法可用于制剂和废水中头孢噻肟的测定，平均回收率分别为99.73%和98.51%。

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Analytical Chemistry Research

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