Neuroprotective effect of Capparis ovata Desf. var. palaestina Zoh. on H2O2‐induced neurotoxicity in SH‐SY5Y cells

IF 0.7 4区医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2023-07-30 DOI:10.37360/blacpma.23.22.4.32

A. Arslan, Kubra Olagan, Leyla Paşayeva

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Abstract

The neuroprotective effect of flower and fruit parts of Capparis ovataDesf. var. palaestinaZoh. plant was investigated in H2O2-induced cytotoxicity in SH-SY5Y cells. The cells were treated with H2O2alone or pretreated with flower (COMFL) and fruit extract (COMFR) of C. ovatavar. palaestina. MTT, xCELLigence, and qualitative and quantitative determination of phytochemical constituents in the extracts by LC-MS/MS methods were employed. COMFL and COMFR had a neuroprotective effect and this effect was stronger when the presence of oxidative stress. The mass spectrums revealed the presence of flavonoids and phenolic acid derivatives in the extracts. According to quantitative analyses, the main compounds were myristoleic acid, apigenin, caffeic acid, caffeic acid-3-glucoside, and 5-cynapoil quinic acid in both COMFL and COMFR and rutin was found in COMFL. The extracts could inhibit H2O2induced neuronal cell death whichmight be beneficial for the pretreatment of oxidative stress in neurodegenerative diseases

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羊角草的神经保护作用。变体巴勒斯坦左H2O2诱导SH - SY5Y细胞神经毒性的研究

黄荆花果部分的神经保护作用。var. palaestinaZoh。研究了h2o2诱导SH-SY5Y细胞的细胞毒性。细胞分别用h2o2单独处理或用花(COMFL)和果提取物(COMFR)预处理。巴勒斯坦。采用MTT、xCELLigence、LC-MS/MS对提取物中的植物化学成分进行定性和定量分析。COMFL和COMFR具有神经保护作用，且在氧化应激条件下作用更强。质谱分析表明，提取物中含有黄酮类化合物和酚酸衍生物。定量分析发现，COMFL和COMFR中主要化合物为肉豆蔻烯酸、芹菜素、咖啡酸、咖啡酸-3-葡萄糖苷和5-氨基乙酸奎宁酸，COMFL中含有芦丁。其提取物对h2o2诱导的神经元细胞死亡具有抑制作用，可能有助于神经退行性疾病氧化应激的预处理

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来源期刊

Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas PHARMACOLOGY & PHARMACY-

CiteScore

1.30

自引率

14.30%

发文量

审稿时长

6-12 weeks

期刊介绍： The Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas (BLACPMA), [Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants]; currently edited by the publishing house MS-Editions, is a bi-monthly international publication that publishes original peerreviewed research in the field of medicinal and aromatic plants, with nearly 20 years of experience. BLACPMA is a scientific journal that publishes two types of articles: Reviews (only in English) and Original Articles (Spanish or English), its main lines of action being agronomy, anthropology and ethnobotany, industrial applications, botany, quality and standardization, ecology and biodiversity, pharmacology, phytochemistry, pharmacognosy, regulatory and legislative aspects. While all areas of medicinal plants are welcome and the experimental approaches used can be broad and interdisciplinary; other areas of research that are not mentioned depend on the Editorial Committee for their acceptance.