The effect of regular exercise training on gene expression of Autophagy related protein 5 (ATG5) and Autophagy related protein 7 (ATG7) of white adipose tissue of mice with a high-fat diet

S. Daneshyar, A. Khosravi, F. Omidali, S. Shokati Basir
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Abstract

high-fat Regular exercise training could augment the HFD-induced upregulation of ATG7 expression. However, it could not the HFD-induced upregulation of ATG5 gene expression. Based on the results could be exercise training accompanied by a high-fat diet may stimulate the autophagy mechanism in white adipose tissue, resulting in a positive adaptation in white adipose tissue development.
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定期运动训练对高脂饮食小鼠白色脂肪组织中自噬相关蛋白5 (Autophagy related protein 5, ATG5)和自噬相关蛋白7 (Autophagy related protein 7, ATG7)基因表达的影响
定期运动训练可增强hfd诱导的ATG7表达上调。然而,它不能引起hfd诱导的ATG5基因表达上调。综上所述,运动训练配合高脂饮食可能会刺激白色脂肪组织的自噬机制,从而对白色脂肪组织的发育产生积极的适应作用。
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