{"title":"Crystal Structure of Dichlorobis(N-{4-[(2-pyrimidinyl-κN-amino)-sulfonyl]phenyl}acetamide)copper(II)","authors":"J. Obaleye, M. Caira, A. Tella","doi":"10.2116/ANALSCIX.24.X63","DOIUrl":null,"url":null,"abstract":"The X-ray structure of the complex dichlorobis(N-{4-[(2-pyrimidinyl-κN-amino)sulfonyl]phenyl}acetamide)copper(II), containing a metabolite N4-acetylsulfadiazine (or N-{4-[(2-pyrimidinylamino)sulfonyl]phenyl}acetamide) of the antibacterial sulfadiazine as ligand, is reported. The complex crystallizes in the space group P21/n with a = 12.7531(3)A, b = 8.0777(2)A, c = 14.8548(3)A, β = 112.237(1)°, and Z = 2, requiring it to be centrosymmetric. Two chloride ions and two N4-acetylsulfadiazine molecules are coordinated to the metal center, each organic moiety being bonded to Cu(II) through a pyrimidinyl nitrogen atom. The metal coordination sphere includes carbonyl oxygen atoms from symmetry-related complex molecules at the apical sites of the square-planar unit, CuN2Cl2, giving a tetragonally-distorted octahedral geometry around Cu(II). Although N4-acetylsulfadiazine, itself, has not demonstrated antibacterial activity, the title complex showed moderate growth inhibition of several bacteria in in vitro assays.","PeriodicalId":7796,"journal":{"name":"Analytical Sciences: X-ray Structure Analysis Online","volume":"52 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Analytical Sciences: X-ray Structure Analysis Online","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2116/ANALSCIX.24.X63","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3
Abstract
The X-ray structure of the complex dichlorobis(N-{4-[(2-pyrimidinyl-κN-amino)sulfonyl]phenyl}acetamide)copper(II), containing a metabolite N4-acetylsulfadiazine (or N-{4-[(2-pyrimidinylamino)sulfonyl]phenyl}acetamide) of the antibacterial sulfadiazine as ligand, is reported. The complex crystallizes in the space group P21/n with a = 12.7531(3)A, b = 8.0777(2)A, c = 14.8548(3)A, β = 112.237(1)°, and Z = 2, requiring it to be centrosymmetric. Two chloride ions and two N4-acetylsulfadiazine molecules are coordinated to the metal center, each organic moiety being bonded to Cu(II) through a pyrimidinyl nitrogen atom. The metal coordination sphere includes carbonyl oxygen atoms from symmetry-related complex molecules at the apical sites of the square-planar unit, CuN2Cl2, giving a tetragonally-distorted octahedral geometry around Cu(II). Although N4-acetylsulfadiazine, itself, has not demonstrated antibacterial activity, the title complex showed moderate growth inhibition of several bacteria in in vitro assays.
报道了以抗菌磺胺嘧啶代谢物n4 -乙酰磺胺嘧啶(或N-{4-[(2-嘧啶氨基-κN-氨基)磺酰基]苯基乙酰胺)为配体的配合物二氯苯(N-{4-[(2-嘧啶氨基)磺酰基]苯基乙酰胺)铜(II)的x射线结构。配合物在P21/n空间群中结晶,a = 12.7531(3) a, b = 8.0777(2) a, c = 14.8548(3) a, β = 112.237(1)°,Z = 2,要求其中心对称。两个氯离子和两个n4 -乙酰磺胺嘧啶分子配位在金属中心,每个有机部分通过一个嘧啶基氮原子与Cu(II)结合。金属配位球包括来自对称相关络合物分子的羰基氧原子,位于方形平面单元CuN2Cl2的顶端,在Cu(II)周围形成四方扭曲的八面体几何。虽然n4 -乙酰磺胺嘧啶本身没有显示出抗菌活性,但在体外实验中,标题复合物显示出对几种细菌的适度生长抑制。