First Synthesis of N-(4-Fluorophenyl)-5-(4-fluorophenyl)-2-(4-hydroxybenzyl)pentanamide, a New Potential Cholesterol Absorption Inhibitor

Abstract

The first synthesis of N-(4-fluorophenyl)-5-(4-fluorophenyl)-2-(4-hydroxybenzyl)pentanamide and a new synthesis of 1-(4-fluorophenyl)-3-[(4-fluorophenyl)propyl]-4-(4-hydroxyphenyl)-2-azetidinone starting from 4-fluorobenzaldehyde are described. This new amide could represent a potential new cholesterol absorption inhibitor.