Jing-tao Wu, Lei Zhou, Gui-wen Yang, F. Tao, Mao-shan Wang, Jian-guo Hu
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引用次数: 0
Abstract
Background: Platycodin D (PD) is one of the important active ingredients in the root of the Platycodon grandiflorum
(Jacq.) A. DC (PG), a traditional medicine with many pharmacological activities, especially hepatoprotective activity.
There are some researches on the mechanism of liver protection, but it is not very clear. It is necessary to investigate it
deeply.
Materials and Methods: In order to evaluate the effect of PD on ethanol-induced fatty liver (EFL) and investigate the
possible mechanism, the EFL models of rats and BRL-3A cells were set up and treated with PD of 20, 30 mg/kg body
weight/day for four weeks, respectively. The hepatic histochemistry, liver function enzymes, oxidative stress levels,
antioxidant enzymes and signal path enzymes were assayed.
Results: PD significantly (P
期刊介绍：
The “African Journal of Traditional, Complementary and Alternative Medicines (AJTCAM)” is a peer-reviewed, multidisciplinary, international, scientific Open Access Journal that provides publication of articles on phytomedicines, ethnomedicines and veterinary ethnomedicines. The journal is published by a Non-Governmental Organization (NGO) known as “African Traditional Herbal Medicine Supporters Initiative (ATHMSI)”. The Journal welcomes submission of manuscripts that meet the general criteria of significance and scientific excellence. Papers will be published approximately two-to-three months after acceptance
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