Seborrheic dermatitis: the choice of topical treatment tactics, taking into account the characteristics of the skin microbiome

Abstract

Objective — to study the clinical efficacy and safety of Betasalic, Triacutan and Psoricap drugs in the treatment of patients with seborrheic dermatitis. Materials and methods. The study included 75 patients with seborrheic dermatitis (main group). The control group consisted of 56 healthy individuals of the same age. The severity of seborrheic dermatitis in patients was assessed on a point scale, which included the assessment of the intensity of erythema, edema, oozing lesions, excoriation, scaling, skin oiliness. The study of skin microbiocenosis was carried out by the method of its direct qualitative and quantitative assessment. The level of anxiety was assessed using the Spielberger—Khanin self-assessment scale. Depending on the proposed treatment, patients with seborrheic dermatitis were divided into 2 groups: Group I (experimental group) — 43 patients who received Betasalic for 5 days, Triacutan — for 5 days, Psoricap — for 18 days starting from the 11th day of therapy; Group II (comparison group) — 32 patients who received topical corticosteroids. Results and discussion. The course of seborrheic dermatitis is accompanied by disorders of the skin microbiocenosis with an increase in the number of fungi of Malassezia and Candida genus in the affected areas, which requires appropriate treatment. Patients with seborrheic dermatitis are characterized by the presence of high personal and situational anxiety. The inclusion of Betasalic and Triacutan in the standard therapy of seborrheic dermatitis contributed to the recovery of the majority of patients and a significant improvement in different localizations of the pathological process. In contrast to the experimental subgroup, in the subgroup with standard treatment, these rates were significantly lower. Additional inclusion of Psoricap in the treatment regimen of patients with seborrheic dermatitis led to the recovery of 100 % of patients with the localization of the pathological process on the scalp and face. Conclusions. Complex therapy of seborrheic dermatitis with the use of Betasalic ointment, Triacutan cream or ointment and Psoricap cream is pathogenetically proved, since it provides a quick clinical effect, normalization of skin microbiocenosis.