Alzheimer’s Disease (AD): Risks, Treatments, Prevention, and Future Implementations

T. Huma, Rukhsana Nawaz, Xiaohua Li, Andrew Willden
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引用次数: 3

Abstract

Alzheimer’s disease (AD) is the most common type of dementia found among geriatric populations worldwide and is growing quickly in low- and middle-income countries. Alzheimer’s disease affects approximately 36.6 mil-lion people, and that number is expected to double over the next two decades. Those most susceptible to Alzheimer’s are over the age of 60, though other associated factors such as sex, poor nutrition, education, impaired functional status, body mass index, diabetes, depression, smoking, alcohol, fish intake, and pesticide exposure have been reported, though none are clear. Gaining a better understanding of the etiology of AD requires multiple-site-targeted therapy to control the disease at the initial level. On the other hand, evidence suggests that risk factors for AD are modifiable. Hence reduction in associated risk factors may require very long follow-ups to make people aware of their effect on AD incidence. If these factors are effective in preventing the progression of AD, the target populations could be affected at the early stages of AD or even patients with more advanced disease.
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阿尔茨海默病(AD):风险、治疗、预防和未来实施
阿尔茨海默病(AD)是全世界老年人群中最常见的痴呆症类型,在低收入和中等收入国家增长迅速。阿尔茨海默病影响了大约3660万人,预计这一数字在未来20年将翻一番。最容易患阿尔茨海默氏症的是60岁以上的人,尽管其他相关因素,如性别、营养不良、教育程度、功能受损、体重指数、糖尿病、抑郁、吸烟、饮酒、摄入鱼类和接触农药,都有报道,但都不清楚。为了更好地了解阿尔茨海默病的病因,需要多位点靶向治疗以在初始水平控制疾病。另一方面,有证据表明阿尔茨海默病的危险因素是可以改变的。因此,减少相关风险因素可能需要很长时间的随访,以使人们意识到它们对阿尔茨海默病发病率的影响。如果这些因素能够有效地预防AD的进展,那么目标人群可能会在AD的早期阶段甚至是更晚期的患者中受到影响。
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