A review on micro RNAs and its application in psoriasis

Abstract

Psoriasis is a chronic and multifactorial autoimmune disorder in skin. In case of Psoriasis there is an abnormal hyper proliferation in keratinocytes, arised due to the activation of T-cells which produces a rich amount of arachidonic acid which leads to generation of various pro inflammatory mediators like PGs, LTs, cytokines and adhesion molecules via MAPK/AP-1, EARK1/2 and protein kinase-C (PKCs) activation pathways.1 In order to treat Psoriasis there is a need for the incorporation of naturally occuring bioactives like, omega (ω)-3 fatty acids (i.e., EPA and DHA) in a dose dependent manner which results in the inhibition of various pro-inflammatory mediators. Metabolization of EPA and DHA leads to the dampening of inflammation and higher resolution of abnormalities in skin. In case of natural treatment the synthesis of ω-3 PUFA-derived lipid mediators, namely resolvins and protectins have been widely used alone or in combination with other drugs in the treatment. Despite of their meritorious visages, the use of these bioactives is associated with several hiccups like higher range of instability and vulnerable to degradation due to lipid per oxidation. This treatment is also resulted in poor and inconsistent bioavilability by oral and topical administration. The potential use of nanomedicines in the delivery of such bio-actives has gained wider attention owing to their promise in enhancing the characteristics of bioavailability, improved stability and better efficacy. Moreover, barriers in the effective delivery of ω-3 fatty acids and how nanomedicines can be fit in the scope of its therapeutic delivery in psoriasis have also been addressed but it still has a long way to go with multidisciplinary aspects like Pharmacogenomics.