{"title":"Inhibitory effects of ascaris suum extract On gastric acid secretion in rats","authors":"R. Nwankwoala, O. Georgewill, U. Georgewill","doi":"10.5580/26c4","DOIUrl":null,"url":null,"abstract":"The effects of Ascars Suum (A. Suum) extract on gastric acid secretion were investigated in urethane-anaesthetised rats. Three determinations were done viz (1) the acid content when no drug was administered (2) the acid content when histamine was injected and (3) the acid content when the A. Suum extract was given alone or after histamine was administered. The extract (5.5 or 14mg/kg) reduced histamine-induced gastric acid secretion to the control value. At 14mg/kg the extract also reduced basal gastric acid secretion. At the peak of histamine-induced gastric acid secretion, the administration of the extract promptly reduced the gastric acid secretion to basal values. These results indicate that extracts of Ascaris Suum inhibit gastric acid secretion.","PeriodicalId":22523,"journal":{"name":"The Internet Journal of Pharmacology","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Internet Journal of Pharmacology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5580/26c4","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The effects of Ascars Suum (A. Suum) extract on gastric acid secretion were investigated in urethane-anaesthetised rats. Three determinations were done viz (1) the acid content when no drug was administered (2) the acid content when histamine was injected and (3) the acid content when the A. Suum extract was given alone or after histamine was administered. The extract (5.5 or 14mg/kg) reduced histamine-induced gastric acid secretion to the control value. At 14mg/kg the extract also reduced basal gastric acid secretion. At the peak of histamine-induced gastric acid secretion, the administration of the extract promptly reduced the gastric acid secretion to basal values. These results indicate that extracts of Ascaris Suum inhibit gastric acid secretion.
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