Effect of Position of Nonflat Punch on-Dividing Properties of Scored Tablet in One Side Compaction Method

Journal of the Nippon Hospital Pharmacists Association Pub Date : 1991-01-01 DOI:10.5649/jjphcs1975.17.306

A. Ito, M. Sugihara

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Abstract

The significance of the position of nonflat punch on dividing prcperties of scored tablets was investigated in several tablets prepared from excipients or granules by one side compaction method.For the excipients, lactose, perfiller®and microcrystalline cellulose were used.For the granules, sieved granules in 12-16, 16-32 and 32-48 mesh incorporating either hydroxy propyl cellulose or potato starch as binder was used.Different influence of the position of nonflat punch on dividing strength of scored tablets was observed between the case of excipients and granules.Dividing strength of scored tablets made from excipients was not affected by the position of nonflat punch.But tablets made from granules had a tendency to show high dividing strength when tablets were compressed by nonflat upper punch.Then weight variation of divided tablets showed a tendency to become less when compressed by nonflat upper punch in both tablets made from excipients and granules.It was suggested that the effect of the position of nonflat punch on dividing properties of scored tablets was caused by different pressure lines during tablet compression.

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非平冲头位置对单侧压实法压痕片分型性能的影响

采用单侧压实法制备辅料片和颗粒剂片，考察了非平冲孔位置对刻划片剂分划性能的影响。辅料采用乳糖、填充剂®和微晶纤维素。对于颗粒，采用12- 16,16 -32和32-48目的过筛颗粒，其中含有羟基丙基纤维素或马铃薯淀粉作为粘合剂。观察了不同辅料和颗粒剂情况下，非平冲孔位置对刻痕片分度强度的影响。辅料刻痕片的分度强度不受非平冲头位置的影响。而颗粒剂在非平面上压片时，有较高的分片强度的趋势。辅料片和颗粒剂片在非平面上压后，分片重量变化均呈减小的趋势。结果表明，压片过程中不同的压线对非平冲孔位置对压片分型性能的影响是由压片过程中不同的压线引起的。

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Journal of the Nippon Hospital Pharmacists Association

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