Giao N. Ngô, SunMin Park, Hailey M. Stack, J. Rourke, Jennifer A. Melanson, S. Westcott
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引用次数: 0
Abstract
This study reports the synthesis and characterization of a limited number of novel boron-containing and boron-omitted capsaicinoids, providing 12 unique substrates. We have previously reported boron-containing capsaicinoids that showed improved bioactivity compared to capsaicin itself but have yet to test a series of analogous boron-omitted substrates as a direct comparison. The boron-containing capsaicinoids bear a pinacolboronate ester (Bpin) group, which was incorporated using an iridium-catalyzed hydroboration reaction. We report that although nearly all compounds display moderate cytotoxic activity that bests that of capsaicin against human colon HCT116 cancer cells, the activity of our boron-omitted capsaicinoids surpasses that of the boron-containing analogues.
期刊介绍：
Published since 1929, the Canadian Journal of Chemistry reports current research findings in all branches of chemistry. It includes the traditional areas of analytical, inorganic, organic, and physical-theoretical chemistry and newer interdisciplinary areas such as materials science, spectroscopy, chemical physics, and biological, medicinal and environmental chemistry. Articles describing original research are welcomed.
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