Effect of Continuous 6 Months Oral Antioxidant Combination with Universally recommended Dosage in Idiopathic Male Infertility

Q4 Medicine International Journal of Infertility and Fetal Medicine Pub Date : 2016-04-01 DOI:10.5005/JP-JOURNALS-10016-1118

R. Chattopadhyay, S. Yasmin, B. Chakravarty, K. Rao

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引用次数: 4

Abstract

The aim of the present study was to observe the adverse effects of high level of reactive oxygen species (ROS) in idiopathic male infertility and the role of a combined antioxidant therapy for six months to overcome the detrimental effects of ROS. A prospective study including 185 infertile male was conducted at Institute of Reproductive Medicine (IRM) from January 2014 to April 2015. All the major sperm parameters as well as ROS, antioxidant level and the effect of high ROS level were evaluated before and after the therapy. A significant improvement in sperm motility and concentration were observed after 6 months of therapy. Antioxidant level had increased and ROS level had decreased significantly after the antioxidant treatment. Improvement in morphology and leukocyte concentration were observed though not clinically significant. Conclusion: This combined antioxidant therapy may improve sperm quality after continuous 6 months of treatment. However, further study is needed regarding this experiment for validating the trend.

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普遍推荐剂量连续6个月口服抗氧化剂治疗特发性男性不育症的效果

本研究的目的是观察高水平活性氧(ROS)对特发性男性不育症的不良影响，以及6个月联合抗氧化治疗对克服ROS有害影响的作用。2014年1月至2015年4月在生殖医学研究所(IRM)对185名不育男性进行前瞻性研究。观察治疗前后精子各项主要指标及ROS、抗氧化水平及高ROS水平的影响。治疗6个月后，观察到精子活力和浓度有显著改善。抗氧化处理后，抗氧化水平显著升高，ROS水平显著降低。观察到形态学和白细胞浓度的改善，但没有临床意义。结论:连续治疗6个月后，联合抗氧化治疗可提高精子质量。然而，这一趋势还需要进一步的研究来验证。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Infertility and Fetal Medicine Medicine-Reproductive Medicine

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0.20

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