Strategies for thymus regeneration and generating thymic organoids

Amiet Chhatta , Harald M.M. Mikkers , Frank J.T. Staal
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引用次数: 7

Abstract

The thymus plays a crucial role in adaptive immunity through the regulation of T cell development. Thymus dysfunction can have a number of implications, such as increased predisposition to infection and autoimmunity, age-related reduced response to vaccines, and increased risk of cancer development. This review describes several strategies to treat thymic impairment, including endogenous regeneration by growth factor administration, cellular and stem cell therapy, gene therapy and combinations thereof.

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胸腺再生及胸腺类器官生成策略
胸腺通过调节T细胞的发育在适应性免疫中起着至关重要的作用。胸腺功能障碍可能有许多含义,例如感染和自身免疫的易感性增加,与年龄相关的疫苗反应降低,以及癌症发展的风险增加。本文综述了几种治疗胸腺损伤的策略,包括生长因子内源性再生、细胞和干细胞治疗、基因治疗及其联合治疗。
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