Amiet Chhatta , Harald M.M. Mikkers , Frank J.T. Staal
{"title":"Strategies for thymus regeneration and generating thymic organoids","authors":"Amiet Chhatta , Harald M.M. Mikkers , Frank J.T. Staal","doi":"10.1016/j.regen.2021.100052","DOIUrl":null,"url":null,"abstract":"<div><p>The thymus plays a crucial role in adaptive immunity through the regulation of T cell development. Thymus dysfunction can have a number of implications, such as increased predisposition to infection and autoimmunity, age-related reduced response to vaccines, and increased risk of cancer development. This review describes several strategies to treat thymic impairment, including endogenous regeneration by growth factor administration, cellular and stem cell therapy, gene therapy and combinations thereof.</p></div>","PeriodicalId":94333,"journal":{"name":"Journal of immunology and regenerative medicine","volume":"14 ","pages":"Article 100052"},"PeriodicalIF":0.0000,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.regen.2021.100052","citationCount":"7","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of immunology and regenerative medicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468498821000159","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 7
Abstract
The thymus plays a crucial role in adaptive immunity through the regulation of T cell development. Thymus dysfunction can have a number of implications, such as increased predisposition to infection and autoimmunity, age-related reduced response to vaccines, and increased risk of cancer development. This review describes several strategies to treat thymic impairment, including endogenous regeneration by growth factor administration, cellular and stem cell therapy, gene therapy and combinations thereof.