Formulation, evaluation and optimization of stomach specific in situ gel of clarithromycin and metronidazole benzoate

Abstract

The present investigation deals with the formulation, optimization and evaluation of sodium alginate based In situ gel of Clarithromycin and Metronidazole Benzoate. Sodium alginate used as a polymer and CaCO3 was used as a cross-linking agent. The In situ formulation exhibited well, viscosity, drug content and sustained drug release; this study reports that oral administration of aqueous solutions containing sodium alginate results in formation of In situ gel, such formulations are homogenous liquid when administered orally and become gel at the contact site. The results of a 32 full factorial design revealed that the concentration of sodium alginate and concentration of CaCO3 significantly affected the dependent variables Q1, Q12 and T80. These In situ gels are, thus, suitable for oral sustained release of Clarithromycin and Metronidazole Benzoate. Keywords: In situ gel; Stomach specific; Gastric residence time.