Synthesis, Characterization and Antimicrobial Activities of some Novel 3-(4-Bromobenzyl)-5-(Thiophen-2-yl)-4H-1,2,4-Triazol Derivatives

A. Kaneria, Nilesh M. Thumar, K. Ladva, M. Vadodaria
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引用次数: 1

Abstract

A convenient and promising synthesis of 4-(alkyl/aryl)- 3-(4-bromobenzyl)-5-(thiophen-2-yl)-4H-1,2,4-triazol was carried out by the reaction of 2-(4-bromobenzyl)-5-(thiophen-2-yl)-1,3,4-oxadiazole with different aliphatic/aromatic primary amine without any solvent. The newly synthesized compound were characterized by 1H NMR, IR and Mass spectroscopy and also screened for their antimicrobial activity against various strains of bacteria and fungi.
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新型3-(4-溴苯基)-5-(噻吩-2-基)- 4h -1,2,4-三唑衍生物的合成、表征及抗菌活性研究
以2-(4-溴苯)-5-(噻吩-2-基)-1,3,4-恶二唑与不同的脂肪族/芳香族伯胺为原料,在无溶剂条件下合成了4-(烷基/芳基)- 3-(4-溴苯基)-5-(噻吩-2-基)- 4h -1,2,4-三唑。新合成的化合物经1H NMR、IR和质谱表征,并对其抑菌活性进行了筛选。
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