A simple practice guide for dose conversion between animals and human

Anroop B Nair, Shery Jacob
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引用次数: 3272

Abstract

Understanding the concept of extrapolation of dose between species is important for pharmaceutical researchers when initiating new animal or human experiments. Interspecies allometric scaling for dose conversion from animal to human studies is one of the most controversial areas in clinical pharmacology. Allometric approach considers the differences in body surface area, which is associated with animal weight while extrapolating the doses of therapeutic agents among the species. This review provides basic information about translation of doses between species and estimation of starting dose for clinical trials using allometric scaling. The method of calculation of injection volume for parenteral formulation based on human equivalent dose is also briefed.
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动物和人之间剂量转换的简单实践指南
在开展新的动物或人体实验时,了解物种间剂量外推的概念对药物研究人员很重要。从动物到人的剂量转换的种间异速缩放是临床药理学中最具争议的领域之一。异速测量法在推断不同物种间治疗剂的剂量时,考虑了与动物体重有关的体表面积的差异。这篇综述提供了物种间剂量转换的基本信息,以及使用异速缩放法估计临床试验的起始剂量。并简要介绍了基于人体等效剂量的注射量计算方法。
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