A meta-analysis and of clinical values of 11 blood biomarkers, such as AFP, DCP, and GP73 for diagnosis of hepatocellular carcinoma.

IF 4.9 2区医学 Q1 MEDICINE, GENERAL & INTERNAL Annals of medicine Pub Date : 2023-12-01 DOI:10.1080/07853890.2022.2153163

Bing-Yao Pang, Yan Leng, Xiaoli Wang, Yi-Qiang Wang, Li-Hong Jiang

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Abstract

Background: Hepatocellular carcinoma lacks ideal diagnostic biomarkers. There is a lack of scientific evaluation of relevant promising biomarkers as well. Therefore this study reanalyzes the related studies of 11 blood biomarkers of HCC, and compares the diagnostic value of these biomarkers for HCC systematically.

Methods: The relevant literatures on the diagnostic value in HCC of 11 blood indexes in recent 5 years were searched in PubMed, Embase, and Cochrane libraries. Data were extracted and analyzed.

Results: Finally, 83 literature studies were brought into meta-analysis. The pooled sensitivity and specificity of AFP were 0.61 and 0.87, respectively. The AUC of AFP were 0.78. The AUC and sum of sensitivity and specificity of the combination of AFP and other biomarkers were all significantly higher than that of AFP, including AFP + AFP-L3 + DCP, AFP + DCP, AFP/DCP, AFP + GPC3. Among other biomarkers, the AUC and sum of sensitivity and specificity of biomarkers including DCP, GPC3, GP73, Hsp90alpha, midkine, and OPN were significantly higher than that of AFP. In this study, GP73 had the highest sum of sensitivity and specificity (1.78) and AUC (0.95).

Conclusions: The pooled sensitivity and specificity of AFP were 0.61 and 0.87, respectively. The AUC of AFP were 0.78. The combination of AFP and other biomarkers improved the diagnostic efficiency. The diagnostic value of biomarkers including DCP, GPC3, GP73, Hsp90alpha, midkine, and OPN was higher than that of AFP. GP73 had the best diagnostic value for HCC with the highest sum of sensitivity and specificity (1.78) and AUC (0.95).KEY MESSAGESThe pooled sensitivity and specificity of AFP were 0.61 and 0.87, respectively. The AUC of AFP were 0.78. The combination of AFP and other biomarkers improved the diagnostic efficiency of HCC.The diagnostic value of biomarkers including DCP, GPC3, GP73, Hsp90alpha, midkine, and OPN was higher than that of AFP.GP73 had the best diagnostic value for HCC.

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对AFP、DCP、GP73等11种血液生物标志物在肝癌诊断中的临床价值进行荟萃分析。

背景：肝细胞癌缺乏理想的诊断生物标志物。也缺乏对相关有前景的生物标志物的科学评估。因此，本研究重新分析了11种HCC血液生物标志物的相关研究，并系统比较了这些生物标志物对HCC的诊断价值。方法：查阅近5年来11项血液指标对HCC诊断价值的相关文献年在PubMed、Embase和Cochrane图书馆进行了检索。对数据进行提取和分析。结果：83篇文献纳入荟萃分析。AFP的合并敏感性和特异性分别为0.61和0.87。AFP的AUC为0.78。AFP和其他生物标志物组合的AUC、敏感性和特异性总和均显著高于AFP，包括AFP + AFP-L3 + DCP、AFP + DCP，AFP/DCP，AFP + GPC3。在其他生物标志物中，包括DCP、GPC3、GP73、Hsp90alpha、midkine和OPN在内的生物标志物的AUC以及敏感性和特异性之和显著高于AFP。在本研究中，GP73的敏感性和特异性之和最高（1.78），AUC最高（0.95）。结论：AFP的合并敏感性和特异度分别为0.61和0.87。AFP的AUC为0.78。AFP和其他生物标志物的结合提高了诊断效率。DCP、GPC3、GP73、Hsp90alpha、midkine和OPN等生物标志物的诊断价值高于AFP。GP73对HCC的诊断价值最高，敏感性和特异性之和最高（1.78），AUC最高（0.95）。AFP的AUC为0.78。AFP和其他生物标志物的结合提高了HCC的诊断效率。DCP、GPC3、GP73、Hsp90alpha、midkine和OPN等生物标志物对HCC的确诊价值高于AFP。GP73对HCC诊断价值最高。

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来源期刊

Annals of medicine 医学-医学：内科

CiteScore

4.90

自引率

0.00%

发文量

292

审稿时长

3 months

期刊介绍： Annals of Medicine is one of the world’s leading general medical review journals, boasting an impact factor of 5.435. It presents high-quality topical review articles, commissioned by the Editors and Editorial Committee, as well as original articles. The journal provides the current opinion on recent developments across the major medical specialties, with a particular focus on internal medicine. The peer-reviewed content of the journal keeps readers updated on the latest advances in the understanding of the pathogenesis of diseases, and in how molecular medicine and genetics can be applied in daily clinical practice.