Expression pattern of peritoneum IL-6 is associated with baseline peritoneal transport function in uremic patients before dialysis.

IF 0.6 4区医学 Q4 ENDOCRINOLOGY & METABOLISM Neuro endocrinology letters Pub Date : 2022-12-29

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Abstract

Objective: This study aimed to investigate the biological factors associated with baseline peritoneal transport in uremic patients before dialysis.

Methods: Thirty patients with uremia were grouped according to their peritoneal dialysate creatinine/serum creatinine ratio (D/P) as high-transport (H, 16 cases) with D/P>0.65 and low-transport (L, 14 cases) with D/P≤0.65 one month after continuous ambulatory peritoneal dialysis treatment. Multi-inflammatory levels such as serum IL-6 and albumin, peritoneal IL-6 level, and microvessel density (MVD) of visceral peritoneal were compared and correlated between the two groups to determine the associated factors.

Results: There were no significant differences in clinical parameters between the two groups (p < 0.05). There were no significant differences in serum IL-6 and albumin between the two groups. However, peritoneal IL-6 and MVD in group H were significantly higher than group L (p=0.012, p=0.044), and they were positively correlated (r=0.368, p=0.045). Furthermore, baseline D/P was positively correlated with IL-6 expressions (r=0.640, p=0.000) and peritoneal MVD (r=0.476, p=0.008), and independently associated with peritoneal IL-6 expression (p=0.004).

Conclusions: The baseline peritoneal transport performance is associated with peritoneal IL-6 expression and MVD but not circulatory IL-6.

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尿毒症患者透析前腹膜IL-6表达模式与基线腹膜转运功能相关

目的:本研究旨在探讨与尿毒症患者透析前基线腹膜转运相关的生物学因素。方法:将30例尿毒症患者根据其腹膜透析液肌酐/血清肌酐比值(D/P)分为D/P>0.65的高转运组(H, 16例)和D/P≤0.65的低转运组(L, 14例)。比较两组患者血清IL-6、白蛋白、腹膜IL-6水平、内脏腹膜微血管密度(MVD)等多种炎症水平，并进行相关性分析，以确定相关因素。结果:两组患者临床参数比较，差异无统计学意义(p < 0.05)。两组患者血清IL-6、白蛋白水平差异无统计学意义。H组腹膜IL-6、MVD显著高于L组(p=0.012, p=0.044)，且两者呈正相关(r=0.368, p=0.045)。此外，基线D/P与IL-6表达(r=0.640, P =0.000)和腹膜MVD (r=0.476, P =0.008)呈正相关，与腹膜IL-6表达独立相关(P =0.004)。结论:基线腹膜运输性能与腹膜IL-6表达和MVD相关，但与循环IL-6无关。

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来源期刊

Neuro endocrinology letters 医学-内分泌学与代谢

CiteScore

1.00

自引率

14.30%

发文量

审稿时长

6 months

期刊介绍： Neuroendocrinology Letters is an international, peer-reviewed interdisciplinary journal covering the fields of Neuroendocrinology, Neuroscience, Neurophysiology, Neuropsychopharmacology, Psychoneuroimmunology, Reproductive Medicine, Chronobiology, Human Ethology and related fields for RAPID publication of Original Papers, Review Articles, State-of-the-art, Clinical Reports and other contributions from all the fields covered by Neuroendocrinology Letters. Papers from both basic research (methodology, molecular and cellular biology, anatomy, histology, biology, embryology, teratology, normal and pathological physiology, biophysics, pharmacology, pathology and experimental pathology, biochemistry, neurochemistry, enzymology, chronobiology, receptor studies, endocrinology, immunology and neuroimmunology, animal physiology, animal breeding and ethology, human ethology, psychology and others) and from clinical research (neurology, psychiatry and child psychiatry, obstetrics and gynecology, pediatrics, endocrinology, immunology, cardiovascular studies, internal medicine, oncology and others) will be considered. The Journal publishes Original papers and Review Articles. Brief reports, Special Communications, proved they are based on adequate experimental evidence, Clinical Studies, Case Reports, Commentaries, Discussions, Letters to the Editor (correspondence column), Book Reviews, Congress Reports and other categories of articles (philosophy, art, social issues, medical and health policies, biomedical history, etc.) will be taken under consideration.